Transforming Healthcare Through Innovation Thomas J. Graham, M.D. Central Florida Partnership August 25, 2016

Contemporary Healthcare Landscape Historic Inflection Point Change is Real & Immediate All Players Affected Value is the New Yardstick “Triple Aim” Measures

Healthcare’s Triple (or Quadruple) Aim Improving Health of Population Enhancing Patient Outcomes Reducing per capita Cost Ensuring Access to Quality Care

Innovation: The Margin of Difference

Defining Innovation

MISSION DRIVEN Innovation’s Triple Aim Improve & Extend Human Life Inspire & Advance Creative Thought Create & Sustain Economic Prosperity

Innovation-Enabled Paradigm Shifts Traditional Relationships Obsolete Vendor-Client vs. Partner Competitor vs. Collaborator Grantor-Grantee vs. Accelerator/Investor Not-for-Profit vs. Not-for-Loss

Innovation-Enabled Paradigm Shifts Specific Healthcare Observations Volume-to-Value Episodic-to-Holistic Hospital-to-Home (or Mobile) Retail/Consumerism Mentality Democratized & Data-Driven

Citizen Scientist/Data Philanthropist

Spheres of Influence Individual & Population Institutional/Organizational Ecosystem/Cluster

Individual & Population Behavioral Burden Ageing as a Disease Brain Health & Longevity Balance Elevating Human Performance

Innovation & The Organization High Innovation Environment Process-Oriented, Metrics-Driven Installing Innovation Architecture Innovation Culture & Maturity “The Champion & The Evangelist”

Results of First Two Decades at CCI (1995-2015) 76 Spin-off Companies, Portfolio >$1B 2,700 Patent Applications 750 Royalty-bearing Licenses $200M State & Federal Grants $12M in Philanthropy $100M Return to Inventors 1,800 Jobs Created Approximate 3:1 ROI Built the Global Innovation Alliance 1 Best-Selling Book

Innovation & The Ecosystem Intergenerational Living Full Ecosystem Participation Economic Cluster Development Innovation & The Transitional Economy

What Happened? Fundamental Failure Ideation Innovation Entrepreneurial Validation & Piloting Translation & Distribution

Net New Job Creation

Tale of Two Cities: Cluster Creation

Advanced Degrees & Per Capita Income

Innovation Report Card: The Bad News Awareness Gap Infrastructure Gap Capital Gap Talent Gap

Innovation Report Card: The Good News Recognition Reaction Resource Resolve

How Do We Win? Success = Innovation X Collaboration

We’re All Going to be Patients

Double Aim

Importance of Community

Many Thanks