Volume 117, Issue 1, Pages (January 2000)

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Volume 117, Issue 1, Pages 191-198 (January 2000) The Relationship Between Gas Delivery Patterns and the Lower Inflection Point of the Pressure-Volume Curve During Partial Liquid Ventilation Gabriela Ferreyra, PT, Sven Goddon, MD, Yuji Fujino, MD, Robert M. Kacmarek, PhD, RRT, FCCP CHEST Volume 117, Issue 1, Pages 191-198 (January 2000) DOI: 10.1378/chest.117.1.191 Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 1 P-V curve of the total respiratory system in arepresentative animal partially filled with PFC. Tangents drawnto the various slopes of the inspiratory curve were used to identifythe LIP and UIP of the curve. CHEST 2000 117, 191-198DOI: (10.1378/chest.117.1.191) Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 2 The effect of increasing PEEP on airway pressureabove PEEP and with volume ventilation during partial liquidventilation are illustrated. The panels depict variations of eachparameter over time as PEEP increased from 0 to 20 cm H2Oby increments of 5 cm H2O in a representative animal.ZEEP = 0 cm H2O PEEP. CHEST 2000 117, 191-198DOI: (10.1378/chest.117.1.191) Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 3 The effect of increasing PEEP on airway pressureabove PEEP and with pressure ventilation during partial liquidventilation. The panels depict variations of each parameter over timeas PEEP increased from 0 to 20 cm H2O by increments of 5 cmH2O in a representative animal. See Figure 2 for otherabbreviations. CHEST 2000 117, 191-198DOI: (10.1378/chest.117.1.191) Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 4 Inspiratory resistance, time to 75% peak , and Pplat minus PEEP during volume ventilationduring partial liquid ventilation at incremental increases in PEEP areillustrated. † = vs 0 cm H2O PEEP, p < 0.05;‡= vs 12.5 cm H2O PEEP, p < 0.05. CHEST 2000 117, 191-198DOI: (10.1378/chest.117.1.191) Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 5 Time to peak , time to peak pressure, andVt with pressure ventilation during PLV at various PEEPlevels are illustrated. See Figure 4 for explanation of symbols. CHEST 2000 117, 191-198DOI: (10.1378/chest.117.1.191) Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 6 Change in quasi-static compliance during volumeventilation (top) and pressure ventilation(bottom) as PEEP was increased from 0 to 20 cmH2O. See Figure 4 for explanation of symbols. CHEST 2000 117, 191-198DOI: (10.1378/chest.117.1.191) Copyright © 2000 The American College of Chest Physicians Terms and Conditions