From: Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model Invest. Ophthalmol. Vis. Sci..

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Date of download: 6/3/2016 The Association for Research in Vision and Ophthalmology Copyright © All rights reserved. From: Amyloid-β Deposits Lead.

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From: Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model Invest. Ophthalmol. Vis. Sci.. 2017;58(2):708-719. doi:10.1167/iovs.16-21060 Figure Legend: Lipids and calcium in human eyes with AMD. d, drusen. (A) Refractile nodule (green) localizes to BLinD (artifactually separated) and not to subretinal drusenoid deposit (SDD). Yellow, outer limit of BLamD. The osmium tannic acid paraphenylenediamine postfixation method stains extracellular lipid in BLinD gray, tan, or brown. (B) Refractile nodules (green) localize to basal mounds (soft druse material) within BLamD. (C) Hard drusen stained with oil red O has many spherules that are basophilic from hematoxylin staining. (D) Hard drusen with many von Kossa–positive spherules. (E) BrM is positive for esterified cholesterol and other oil red O–binding lipid. End-stage druse contains refractile nodules lacking detectable lipid. Overlying RPE and photoreceptors have atrophied. (F) Refractile nodules are von Kossa positive for calcium phosphates (blue arrowhead). Scale bars denote 50 μm in A–D and 20 μm in E and F. Date of download: 11/7/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.