How To Increase Enrollment In Trials C. Michael Gibson, M.S., M.D. Chief, Clinical Research, Beth Israel Deaconess CV Division Chairman, PERFUSE Study Group Chairman of the Board of WikiDoc Foundation, www.wikidoc.org The World’s Open Source Textbook of Medicine Viewed 150 Million Times Annually Harvard Medical School

C. Michael Gibson, MD Consulting: Bristol-Myers Squibb Daiichi Sankyo Eli Lilly and Company Portola Pharmaceuticals, Inc. St. Jude Medical, Inc. Cytori Therapeutics The Medicines Company

C. Michael Gibson, MD Grant Support: Bayer Corporation, Angel Medical Systems, Inc., Atrium Medical Corporation, Ikaria, Inc., Lantheus Medical Imaging, Portola Pharmaceuticals, Inc., St. Jude Medical, Inc., Genentech, Inc., Stealth Peptides, Inc., Volcano Therapeutics, Inc, Johnson and Johnson, Walk Vascular, Merck and Company, Inc. and Sanofi-Aventis

C. Michael Gibson, MD Honoraria: Merck and Company, Inc. Regado Bio-Sciences Baxter International, Inc. Sanofi-Aventis Cardiovascular Research Foundation Consensus Medical Communications

Patient Based Strategies Increase awareness of the trial via: In-Hospital flyers Out patient clinic flyers Local radio: disease state pieces, interviews Local TV: disease state pieces, special interest stories Hospital TV Local newspaper: advertisements, disease state pieces, interviews Targeted email campaigns Billboards Hospital portal Dedicated trial website with appropriate tags & SEO Twitter You Tube interviews with appropriate tags Material must be approved by the IRB!

Strategies You Cannot Use You cannot lead patients to believe that there is a benefit to them personally from participating in the study Provide any monetary incentive to referring doctors (finders fee) You cannot provide any monetary incentive to patients for their participation You can obtain IRB approval to reimburse patients for travel expenses and parking expenses

Healthcare Provider Based Strategies Increase awareness of the trial via: Same as patient based strategies Grand rounds Morning report with housestaff Targeted email strategies Physician blog Letters via snail mail Breakfast / lunch to discuss trial with MDs and RNs Electronic medical record prompts

Strategies You Cannot Use Provide any monetary incentive to referring doctors (finders fee)

Use Of Social Media To Lead Trials