Volume 64, Issue 3, Pages (September 2013)

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Volume 64, Issue 3, Pages 421-430 (September 2013) Immediate Post–Transurethral Resection of Bladder Tumor Intravesical Chemotherapy Prevents Non–Muscle-invasive Bladder Cancer Recurrences: An Updated Meta- analysis on 2548 Patients and Quality-of-Evidence Review Nathan Perlis, Alexandre R. Zlotta, Joseph Beyene, Antonio Finelli, Neil E. Fleshner, Girish S. Kulkarni European Urology Volume 64, Issue 3, Pages 421-430 (September 2013) DOI: 10.1016/j.eururo.2013.06.009 Copyright © 2013 European Association of Urology Terms and Conditions

Fig. 1 Flow diagram outlining search results and final included and excluded studies. BCa=bladder cancer; MIBC=muscle-invasive bladder cancer; IVC=intravesical chemotherapy; RCT=randomized controlled trial; RFI=recurrence-free interval. European Urology 2013 64, 421-430DOI: (10.1016/j.eururo.2013.06.009) Copyright © 2013 European Association of Urology Terms and Conditions

Fig. 2 Risk-of-bias graph: reviews of authors’ judgments about each risk-of-bias item presented as percentages across all included studies. European Urology 2013 64, 421-430DOI: (10.1016/j.eururo.2013.06.009) Copyright © 2013 European Association of Urology Terms and Conditions

Fig. 3 Forest plot comparing recurrence-free interval in patients receiving intravesical chemotherapy versus controls. CI=confidence interval; IV=inverse variance; SE=standard error. European Urology 2013 64, 421-430DOI: (10.1016/j.eururo.2013.06.009) Copyright © 2013 European Association of Urology Terms and Conditions

Fig. 4 Funnel plot examining the possibility of publication bias. The plot was created by comparing the variance with effect size in publications comparing recurrence-free interval of patients receiving intravesical chemotherapy versus controls. SE=standard error. European Urology 2013 64, 421-430DOI: (10.1016/j.eururo.2013.06.009) Copyright © 2013 European Association of Urology Terms and Conditions

Fig. 5 Forest plot comparing early recurrences (within 1 yr) between patients receiving immediate intravesical chemotherapy after transurethral resection of bladder tumor versus controls. CI=confidence interval; IV=inverse variance; SE=standard error. European Urology 2013 64, 421-430DOI: (10.1016/j.eururo.2013.06.009) Copyright © 2013 European Association of Urology Terms and Conditions

Fig. 6 Forest plot comparing bladder cancer progression (to muscle invasion) between patients receiving intravesical chemotherapy after transurethral resection of bladder tumor versus controls. CI=confidence interval; IV=inverse variance; SE=standard error. European Urology 2013 64, 421-430DOI: (10.1016/j.eururo.2013.06.009) Copyright © 2013 European Association of Urology Terms and Conditions