Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure Philipp Badorrek, MD,

Slides:

Advertisements

Similar presentations

Allergic conjunctivitis and dry eye syndrome

Advertisements

Clinical Application of Nasal Filters: An Observational Study on the Usability of Nasal Filters in Managing Seasonal Allergic Rhinitis Peter Kenney,

Mauli Desai, MD, John Oppenheimer, MD

The effects of an anti–IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge Grant C. Nicholson, BSc, Harsha H. Kariyawasam,

Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis Anja P. Mose, MD, Charlotte G. Mortz, MD, PhD,

Oxymetazoline adds to the effectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis Fuad M. Baroody, MD, David Brown, MD,

A proof-of-concept study of the effect of a novel H3-receptor antagonist in allergen- induced nasal congestion William T. Barchuk, MD, Anne Marie Salapatek,

Respiratory Nitric Oxide Levels in Experimental Human Influenza

Volume 130, Issue 4, Pages (October 2006)

Efficacy and safety of birch pollen immunotherapy for local allergic rhinitis Andrzej Bożek, MD, PhD, Krzysztof Kołodziejczyk, MD, PhD, Jerzy Jarząb,

Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma Ronaldo P. Panganiban, BS, Yanli Wang, BS, Judie Howrylak, MD, PhD,

Reduced exhaled nitric oxide values in children with asthma after inpatient rehabilitation at high altitude Johannes Huss-Marp, MD, Ursula Krämer, PhD,

Oral Phenylephrine HCl for Nasal Congestion in Seasonal Allergic Rhinitis: A Randomized, Open-label, Placebo-controlled Study Eli O. Meltzer, MD, Paul.

Petasol butenoate complex (Ze 339) relieves allergic rhinitis–induced nasal obstruction more effectively than desloratadine Alina F. Dumitru, MD, Mohamed.

Ann-Marie M. Schoos, MD, PhD, Jacob D

Allergic Rhinitis and Its Impact on Asthma

Fluticasone furoate nasal spray reduces the nasal-ocular reflex: A mechanism for the efficacy of topical steroids in controlling allergic eye symptoms

Calcitonin gene-related peptide– and vascular endothelial growth factor–positive inflammatory cells in late-phase allergic skin reactions in atopic subjects

Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: A meta-analysis–based comparison Danilo Di.

Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blind pilot trial Jens U. Ponikau, MD, David.

Jennifer L. Ingram, PhD, Monica Kraft, MD

Randomized phase 1 study of the phosphatidylinositol 3-kinase δ inhibitor idelalisib in patients with allergic rhinitis Friedrich Horak, MD, Kamal D.

Clinical Application of Nasal Filters: An Observational Study on the Usability of Nasal Filters in Managing Seasonal Allergic Rhinitis Peter Kenney,

Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma Ronaldo P. Panganiban, BS, Yanli Wang, BS, Judie Howrylak, MD, PhD,

Children with allergic and nonallergic rhinitis have a similar risk of asthma Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,

As-needed use of fluticasone propionate nasal spray reduces symptoms of seasonal allergic rhinitis Albert Jen, MD, Fuad Baroody, MD, Marcy de Tineo,

Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Treatment of Acute Urticaria: A Randomized Double-Blind Clinical Trial

Clara cell 16-kd protein downregulates TH2 differentiation of human naive neonatal T cells Sofi Johansson, MSc, Göran Wennergren, MD, PhD, Nils Åberg,

Nasal allergen provocation test with multiple aeroallergens detects polysensitization in local allergic rhinitis Carmen Rondón, MD, PhD, Paloma Campo,

Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy Weiping Wen, PhD, Wenlong Liu, MD, Luo Zhang, PhD, Jing Bai,

Oxymetazoline adds to the effectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis Fuad M. Baroody, MD, David Brown, MD,

The impact of allergic rhinitis on bronchial asthma

A network-based analysis of the late-phase reaction of the skin

A thymic stromal lymphopoietin–responsive dendritic cell subset mediates allergic responses in the upper airway mucosa Guro R. Melum, MD, Lorant Farkas,

Phillip Lieberman, MD, Michael Tankersley, MD

Blood eosinophils predict therapeutic effects of a GATA3-specific DNAzyme in asthma patients Norbert Krug, MD, Jens M. Hohlfeld, MD, Roland Buhl, MD,

Inhaled allergen bronchoprovocation tests

Chronic rhinosinusitis: Endotypes, biomarkers, and treatment response

A proof-of-concept study of the effect of a novel H3-receptor antagonist in allergen- induced nasal congestion William T. Barchuk, MD, Anne Marie Salapatek,

Recruitment of T cells to the lung in response to antigen challenge

Allergen-specific immunotherapy with recombinant grass pollen allergens Marek Jutel, MD, Lothar Jaeger, MD, Roland Suck, PhD, Hanns Meyer, Dipl Math,

What is an “eosinophilic phenotype” of asthma?

Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis Anja P. Mose, MD, Charlotte G. Mortz, MD, PhD,

Evaluation of Allergen Immunotherapy

Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: A randomized, double-blind clinical trial Michael Weschta, MD, Dagmar Rimek,

Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber Thomas Werfel, MD, Annice Heratizadeh, MD, Margarete.

Nasal AMP and histamine challenge within and outside the pollen season in patients with seasonal allergic rhinitis Sriram Vaidyanathan, MBBS, Peter Williamson,

The effects of an anti–IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge Grant C. Nicholson, BSc, Harsha H. Kariyawasam,

Physiologic assessment of allergic rhinitis in mice: Role of the high-affinity IgE receptor (FcɛRI) Satoko Miyahara, MD, PhD, Nobuaki Miyahara, MD, PhD,

Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract Anil Nanda, MD, Maeve O'Connor, MD,

The National Institutes of Allergy and Infectious Diseases networks on asthma in inner- city children: An approach to improved care William W. Busse,

Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis Carmen Rondón, MD, PhD, Javier.

Intranasal administration of eotaxin increases nasal eosinophils and nitric oxide in patients with allergic rhinitis Toyoyuki Hanazawa, MD, PhD, Julio.

Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis Philippe-Jean Bousquet, MD, Christophe Combescure, PhD,

Objective monitoring of nasal patency and nasal physiology in rhinitis

Efficacy and safety of sublingual tablets of house dust mite allergen extracts: Results of a dose-ranging study in an environmental exposure chamber

Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI in patients with seasonal allergic rhinitis Norbert.

Efficacy of 2 months of allergen-specific immunotherapy with Bet v 1–derived contiguous overlapping peptides in patients with allergic rhinoconjunctivitis:

Alvaro A. Cruz, MD, Robert M

Abnormalities of cell and mediator levels in bronchoalveolar lavage fluid of patients with mild asthma Sally E. Wenzel, MD Journal of Allergy and Clinical.

IL-9 and c-Kit+ mast cells in allergic rhinitis during seasonal allergen exposure: Effect of immunotherapy Kayhan T. Nouri-Aria, PhD, FRCPath, Charles.

Circulatory levels of T-cell cytokines (interleukin [IL]-2, IL-4, IL-17, and transforming growth factor-β) in patients with vitiligo Rehan Khan, MSc,

Interrupting IL-6–receptor signaling improves atopic dermatitis but associates with bacterial superinfection Alexander A. Navarini, MD, PhD, Lars E.

Supplementary Figure S1: Comparison of nasal secretion MS cytokine data from the second allergen challenge (of 12 asthmatics with allergic rhinitis) with.

Sublingual immunotherapy for peanut allergy: Clinical and immunologic evidence of desensitization Edwin H. Kim, MD, J. Andrew Bird, MD, Michael Kulis,

Effect of omalizumab treatment on peripheral eosinophil and T-lymphocyte function in patients with allergic asthma Oliver Noga, MD, Gerald Hanf, MD,

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,

Natural history of cow’s milk allergy

Eosinophil progenitor levels are increased in patients with active pediatric eosinophilic esophagitis David W. Morris, MD, Emily M. Stucke, BA, Lisa.

Elevated serum osteopontin level is associated with blood eosinophilia and asthma comorbidity in patients with allergic rhinitis Wenlong Liu, MD, Wentong.

Presentation transcript:

Specificity and reproducibility of nasal biomarkers in patients with allergic rhinitis after allergen challenge chamber exposure Philipp Badorrek, MD, Meike Müller, PhD, Wolfgang Koch, PhD, Jens M. Hohlfeld, MD, Norbert Krug, MD Annals of Allergy, Asthma & Immunology Volume 118, Issue 3, Pages 290-297 (March 2017) DOI: 10.1016/j.anai.2017.01.018 Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

Figure 1 Mean total nasal symptom score (TNSS) of the last 5 measurements during challenge in healthy participants and patients with allergic rhinitis on challenge day 1 (left) and challenge day 2 (right). The data are displayed in a box-and-whiskers graph. The box extends from the 25th percentile to the 75th percentile, with a line at the median. The whiskers extend to the highest and lowest value. Asterisk indicates a significant (P < .001) difference between healthy participants and patients with allergic rhinitis. Annals of Allergy, Asthma & Immunology 2017 118, 290-297DOI: (10.1016/j.anai.2017.01.018) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

Figure 2 Nasal flow measured by rhinomanometry in healthy participants (left) and patients with allergic rhinitis (right) for challenge day 1 (top) and challenge day 2 (bottom). The data are displayed in a box-and-whiskers graph (see legend for Fig 1). Asterisk indicates a significant decrease (P < .05) compared with baseline (before). Annals of Allergy, Asthma & Immunology 2017 118, 290-297DOI: (10.1016/j.anai.2017.01.018) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

Figure 3 Relative percentage of eosinophils in healthy participants (left) and patients with allergic rhinitis (right) for challenge day 1 (top) and challenge day 2 (bottom). The data are displayed in a box-and-whiskers graph (see legend for Fig 1). Asterisk indicates a significant increase (P < .05) compared with baseline (before). Reproduced with permission from Krug et al12 (copyright 2012 Wiley). Annals of Allergy, Asthma & Immunology 2017 118, 290-297DOI: (10.1016/j.anai.2017.01.018) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

Figure 4 Interleukin (IL) 5 (A), IL-6 (B), and macrophage inflammatory protein (MIP) 1β (C) levels in healthy participants (left) and patients with allergic rhinitis (right) for challenge day 1 (top) and day 2 (bottom). Cytokines were measured in nasal secretion of patients with allergic rhinitis and healthy participants at the times shown in the graphs. The data are displayed in a box-and-whiskers graph (see legend for Fig 1). Asterisk indicates a significant (P < .05) increase and dagger indicates a significant (P < .05) decrease compared with baseline (before). Annals of Allergy, Asthma & Immunology 2017 118, 290-297DOI: (10.1016/j.anai.2017.01.018) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

Figure 5 Interleukin (IL) 13 (A) and eotaxin (B) were measured in nasal secretion–soaked filter papers of patients with allergic rhinitis and healthy participants at the times shown in the graphs. The data are displayed in a box-and-whiskers graph (see legend for Fig 1). Asterisk indicates a significant (P < .05) increase in patients with allergic rhinitis. Annals of Allergy, Asthma & Immunology 2017 118, 290-297DOI: (10.1016/j.anai.2017.01.018) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions

Figure 6 Nasal nitric oxide measurements in healthy participants (left) and patients with allergic rhinitis (right) for challenge day 1 (top) and challenge day 2 (bottom). The data are displayed in a box-and-whiskers graph (see legend for Fig 1). Asterisk indicates a significant increase (P < .05) and dagger indicates a significant decrease (P < .05) compared with baseline (before). Annals of Allergy, Asthma & Immunology 2017 118, 290-297DOI: (10.1016/j.anai.2017.01.018) Copyright © 2017 American College of Allergy, Asthma & Immunology Terms and Conditions