Volume 204, Issue 2, Pages (February 2011)

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Volume 204, Issue 2, Pages 108-110 (February 2011) Secondary PSF/TFE3-associated renal cell carcinoma in a child treated for genitourinary rhabdomyosarcoma María Sol Brassesco, Elvis Terci Valera, Thais Alcantara Bonilha, Carlos Alberto Scrideli, Jaqueline Carvalho de Oliveira, Julia Alejandra Pezuk, Gyl Eanes Barros Silva, Roberto Silva Costa, Luiz Gonzaga Tone Cancer Genetics Volume 204, Issue 2, Pages 108-110 (February 2011) DOI: 10.1016/j.cancergencyto.2010.10.006 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 (a) Xp11.2 translocation-associated renal cell carcinoma with clear-cell features showing nests of malignant cells with intervening thin-walled vessels. The cells demonstrate granular eosinophilic cytoplasm. (b) Nuclei are round to slightly irregular with mildly enlarged nucleoli visible (Fuhrman grade 2). Hematoxylin and eosin stain (×20 objective and ×40 objective). (c) Partial inverted 4′,6-diamidino-2-phenylindole karyotype showing the t(X;1)(p11.2;p34). (d,e) Representative images showing normal chromosomes X and 1 and the translocated derivatives after hybridization to SKY probe mixture (d), and chromosome 1 paint WCP1 (red PlatinunBright550 labeled, Kreatech Diagnostics) (e). (f) Positivity for the PSF-TFE3 fusion gene: weight marker (lane 1), tumor sample (lane 2), negative normal kidney sample (lane 3), and blank (lane 4). Cancer Genetics 2011 204, 108-110DOI: (10.1016/j.cancergencyto.2010.10.006) Copyright © 2011 Elsevier Inc. Terms and Conditions