Simultaneous determination of creatinine and uric acid in urine by liquid chromatography–tandem mass spectrometry with polarity switching electrospray.

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Presentation transcript:

Simultaneous determination of creatinine and uric acid in urine by liquid chromatography–tandem mass spectrometry with polarity switching electrospray ionization Woonyong Kwon, Jin Young Kim, SungIll Suh, Moon Kyo In Forensic Science International Volume 221, Issue 1, Pages 57-64 (September 2012) DOI: 10.1016/j.forsciint.2012.03.025 Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Cr analysis on three analytical columns: (a) a C18 column (Capcell Pak C18 MG-II column, 150mm×2.0mm I.D., 5μm), (b) a phenyl column (Allure PFP propyl, 50mm×2.1mm I.D., 5μm), and (c) a multi-mode C18 column (Scherzo SM-C18, 30mm×2.0mm I.D., 3μm). Forensic Science International 2012 221, 57-64DOI: (10.1016/j.forsciint.2012.03.025) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Representative LC–MS/MS chromatograms, including (a) blank (distilled water) without IS, (b) blank, (c) positive quality control (QCP), (d) Cr and UA positive, and (e) Cr and UA negative samples. Forensic Science International 2012 221, 57-64DOI: (10.1016/j.forsciint.2012.03.025) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Representative LC–MS/MS chromatograms, including (a) blank (distilled water) without IS, (b) blank, (c) positive quality control (QCP), (d) Cr and UA positive, and (e) Cr and UA negative samples. Forensic Science International 2012 221, 57-64DOI: (10.1016/j.forsciint.2012.03.025) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Ion suppression evaluated by monitoring the MRM transitions of Cr, Cr-d3 and UA during post-column infusion of 10ng/min of the analytes and IS for (a) blank (distilled water) and (b) positive quality control (QCP) samples. Forensic Science International 2012 221, 57-64DOI: (10.1016/j.forsciint.2012.03.025) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Distribution pattern of Cr and UA concentration in urine samples obtained from suspected drug abusers (n=46). Forensic Science International 2012 221, 57-64DOI: (10.1016/j.forsciint.2012.03.025) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 Urinary UA/Cr ratio measured by LC–MS/MS. Forensic Science International 2012 221, 57-64DOI: (10.1016/j.forsciint.2012.03.025) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 6 Comparison of urinary Cr and UA concentrations measured by cobas c 311 analyzer and LC–MS/MS. Forensic Science International 2012 221, 57-64DOI: (10.1016/j.forsciint.2012.03.025) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions