Classification and implementation of asthma phenotypes in elderly patients Heung-Woo Park, MD, Woo-Jung Song, MD, Sae-Hoon Kim, MD, Hye-Kyung Park, MD,

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Classification and implementation of asthma phenotypes in elderly patients Heung-Woo Park, MD, Woo-Jung Song, MD, Sae-Hoon Kim, MD, Hye-Kyung Park, MD, Sang-Heon Kim, MD, Yong Eun Kwon, MD, Hyouk-Soo Kwon, MD, Tae-Bum Kim, MD, Yoon-Seok Chang, MD, You-Sook Cho, MD, Byung-Jae Lee, MD, Young-Koo Jee, MD, An- Soo Jang, MD, Dong-Ho Nahm, MD, Jung-Won Park, MD, Ho Joo Yoon, MD, Young-Joo Cho, MD, Byoung Whui Choi, MD, Hee-Bom Moon, MD, Sang-Heon Cho, MD Annals of Allergy, Asthma & Immunology Volume 114, Issue 1, Pages 18-22 (January 2015) DOI: 10.1016/j.anai.2014.09.020 Copyright © 2015 American College of Allergy, Asthma & Immunology Terms and Conditions

Figure 1 Kaplan-Meier plots by cluster of the cumulative probability of a first acute asthma exacerbation in the primary cohort. Cluster 1 indicates long symptom duration and marked airway obstruction; cluster 2, female dominance and normal lung function; cluster 3, smoking male dominance and reduced lung function; and cluster 4, high body mass index and borderline lung function. Annals of Allergy, Asthma & Immunology 2015 114, 18-22DOI: (10.1016/j.anai.2014.09.020) Copyright © 2015 American College of Allergy, Asthma & Immunology Terms and Conditions

Figure 2 Decision-tree algorithm for the classification of elderly patients with asthma in the primary cohort. Cluster 1 indicates long symptom duration and marked airway obstruction; cluster 2, female dominance and normal lung function; cluster 3, smoking male dominance and reduced lung function; and cluster 4, high body mass index and borderline lung function. NPV indicates negative predictive value; PPV, positive predictive value; and PPY indicates pack-year. Annals of Allergy, Asthma & Immunology 2015 114, 18-22DOI: (10.1016/j.anai.2014.09.020) Copyright © 2015 American College of Allergy, Asthma & Immunology Terms and Conditions