Robert Roberts, MD, FRCPC, MACC Canadian Journal of Cardiology

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PCSK9 Inhibition—A New Thrust in the Prevention of Heart Disease: Genetics Does It Again Robert Roberts, MD, FRCPC, MACC Canadian Journal of Cardiology Volume 29, Issue 8, Pages 899-901 (August 2013) DOI: 10.1016/j.cjca.2013.04.014 Copyright © 2013 Canadian Cardiovascular Society Terms and Conditions

Figure 1 This illustrates that low-density lipoprotein (LDL) and its cholesterol (LDL-C) are synthesized in the liver and released into the circulation. The liver is also responsible for removing LDL-C from the circulation. The circulating LDL-C binds to the LDL receptor (LDL-R) on the surface of the liver cells, which internalizes the LDL-C/LDL-R complex to be degraded. Canadian Journal of Cardiology 2013 29, 899-901DOI: (10.1016/j.cjca.2013.04.014) Copyright © 2013 Canadian Cardiovascular Society Terms and Conditions