Silk Fibroin Wound Dressings

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Presentation transcript:

Silk Fibroin Wound Dressings Sierra Obi April 1, 2013 Used for Regenerative Healing Therapies

Cutaneous Wounds Include severe burns, animal bites, skin tears There are numerous wound dressing biomaterials on the market today Tested against an air permeable and a commercial wound dressing product

Silk Fibroin Promising biomaterial Versatile for various biomedical healing applications Mechanical robustness Controllable degradability Safe in acute dermal toxicity

How They Work Silk Fibroin derivative is tested on a full thickness skin wound model or an in vitro human skin model controlled release of signaling molecules Addition of in vivo epidermal growth factor and silver sulfadiazine

Wound Healing Model

Relationship of Wound Size

References http://onlinelibrary.wiley.com/doi/10.1002/adhm.20 1200444/full http://onlinelibrary.wiley.com/doi/10.1002/adhm.20 1200192/full http://www.sciencedirect.com/science/article/pii/S1 742706108004054 http://www.nejm.org/doi/full/10.1056/NEJMra0707 253