Schematic representation of the pathways of PP-ribose-P and purine nucleotide synthesis and the regulation of rates of purine synthesis de novo by PP-ribose-P.

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Schematic representation of the pathways of PP-ribose-P and purine nucleotide synthesis and the regulation of rates of purine synthesis de novo by PP-ribose-P and purine nucleotide end products. Curved arrows depict single-step purine base salvage pathways of purine nucleotide synthesis, requiring PP-ribose-P and catalyzed by the phosphoribosyltransferase (PRT) enzymes, HPRT and adenine PRT. Purine synthesis de novo is shown by a solid arrow (representing the rate-limiting AmidoPRT reaction) and a dashed arrow (depicting the final nine steps in this sequence of reactions). Purine nucleotide inhibition (−) of PP-ribose-P synthetase and AmidoPRT is indicated by the heavy hatched arrow, and allosteric activation (+) of AmidoPRT by PP-ribose-P is shown by the heavy dark arrow. (Reprinted with permission from Becker MA, Kim M, Husain K, Kang T: Regulation of purine nucleotide synthesis in human B lymphoblasts with both hypoxanthine-guanine phosphoribosyltransferase deficiency and phosphoribosylpyrophosphate synthetase superactivity. J Biol Chem 267:4317, 1992; reproduced from previous version of OMMBID Hyperuricemia and Gout chapter written by M. Becker.) Source: Hyperuricemia and Gout, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: https://ommbid.mhmedical.com/DownloadImage.aspx?image=/data/Books/971/ch106fg8.png&sec=62635167&BookID=971&ChapterSecID=62635122&imagename= Accessed: November 09, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved