Plexiform schwannoma mimicking a salivary gland tumor: An unusual case report diagnosed in pediatric patient Jean Nunes dos Santos, Clarissa Araújo Silva.

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Plexiform schwannoma mimicking a salivary gland tumor: An unusual case report diagnosed in pediatric patient Jean Nunes dos Santos, Clarissa Araújo Silva Gurgel, Eduardo Antônio Gonçalves Ramos, Fernando Bastos Pereira Júnior, Iêda Margarida Crusoé-Rebello, Márcio Campos Oliveira International Journal of Pediatric Otorhinolaryngology Extra Volume 6, Issue 4, Pages 317-321 (December 2011) DOI: 10.1016/j.pedex.2011.02.007 Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Plexiform schwannoma. A – non-ulcerated nodule located in the hard palate, measuring 1.6cm×1.5cm. B – computed tomography disclosing a delimited and isodense lesion in the hard palate. C – panoramic view during removal of the tumor. D – gross specimen covered by normal-appearing mucosa. E – hard palate 15 days after surgical excision. F – hard palate 6 months after surgical excision. International Journal of Pediatric Otorhinolaryngology Extra 2011 6, 317-321DOI: (10.1016/j.pedex.2011.02.007) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Plexiform schwannoma. A and B – multiple well-delimited nodules close to normal salivary gland. C – nodules surrounded by a fibrous capsule. D – Antoni A tissue with aligned and compact spindle-shaped cells arranged in a nuclear palisade, and well-developed Verocay bodies as well as small vacuoles. E – Acini and glandular ducts amidst neoplasm. International Journal of Pediatric Otorhinolaryngology Extra 2011 6, 317-321DOI: (10.1016/j.pedex.2011.02.007) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Immunohistochemical findings. A – tumor cells positive for protein S-100. B – Perineurium cells positive for EMA. C – Aligned spindle-shaped cells and Verocay bodies showing immunolabeling for CD56. D – Ki-67 – positive cells were rarely found. E – GFAP-positive spindle-shaped cells were focally observed. International Journal of Pediatric Otorhinolaryngology Extra 2011 6, 317-321DOI: (10.1016/j.pedex.2011.02.007) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions