Fig. 6. Sirtuin 3 (SIRT3) deficiency removes the restorative effect of poly(ADP-ribose) polymerase 1 inhibition on forkhead box O3a (FOXO3a) transcription.

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Fig. 6. Sirtuin 3 (SIRT3) deficiency removes the restorative effect of poly(ADP-ribose) polymerase 1 inhibition on forkhead box O3a (FOXO3a) transcription activity in cisplatin-induced injury to kidney proximal tubule epithelial cells. Luciferase activity was measured in SIRT3-KO or -WT cells transiently transfected with a FOXO3a promoter-reporter (FHRE-Luc) and treated with cisplatin plus PJ34 or vehicle. n=4 experiments in each group. a)P<0.05 versus vehicle. b)P<0.05 versus WT. Fig. 6. Sirtuin 3 (SIRT3) deficiency removes the restorative effect of poly(ADP-ribose) polymerase 1 inhibition on forkhead box O3a (FOXO3a) transcription activity in cisplatin-induced injury to kidney proximal tubule epithelial cells. Luciferase activity was measured in SIRT3-KO or -WT cells transiently transfected with a FOXO3a promoter-reporter (FHRE-Luc) and treated . . . Anat Cell Biol. 2016 Sep;49(3):165-176. http://dx.doi.org/10.5115/acb.2016.49.3.165