Taqman Array Card Results* Cases and Contacts Transmission Cases (22 viral positive cases) hCoV 229E = 3 hCoV NL63 = 1 hCoV OC43 = 8 hCov HKU1 = 5 Influenza A H3 = 6 Parainfluenza-3 = 2 RSV A = 2 RSV B = 4 Average virus + case had 1.4 viral agents detected. Contacts 8 identified as virus infected and enrolled as cases 6 identified as virus infected not enrolled as cases 25 no viral infection detected. Other infections / colonization H influenza = 32 S. pneumonae = 2 7 Contacts became infected after start of surveillance 1 HKU1 & OC43 (contact data only) 1 OC43 2 Influenza A 2 HPIV 1 RSV_B 7 Events available for biomarker discovery 7 Participants infected with both HKU1 & OC43 3 presented with infection as case volunteers 3 presented with infect at 1st contact visit 1 showed infection on 7th follow-up visit * Preliminary subject to verification

Summary PCR Confirmed Attack Rates Influenza Overall attack rate = 9.7% (Jan 31 – Mar 17) Observed ≥ 24h prior to infection = 33% Overall viral illness among 62 enrolled: Attack rate =35% or 0.056/person-week Among 49 enrolled at baseline: 16 viral cases Attack rate = 33% or 0.054/person-week Observed ≥ 24h prior to infection = 32%

Transmission (?) Network Diagram