Josep M. Argilés, PhD, Nefertiti Campos, PhD, José M

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Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease Josep M. Argilés, PhD, Nefertiti Campos, PhD, José M. Lopez-Pedrosa, PhD, Ricardo Rueda, MD, PhD, Leocadio Rodriguez-Mañas, PhD Journal of the American Medical Directors Association Volume 17, Issue 9, Pages 789-796 (September 2016) DOI: 10.1016/j.jamda.2016.04.019 Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine Terms and Conditions

Fig. 1 Glucose metabolism in fed, fasted and malnourished states. A, Glucose, lipids, and amino acids from the diet circulate during the fed state for use or storage in body organs. In the fasted state, glucose is released from the muscles, kidneys, and liver for whole-body metabolism, along with lipids from adipose tissue and amino acids from the muscle. B, When glucose stores have been depleted, amino acids are provided by the muscles to support crucial bodily functions. Journal of the American Medical Directors Association 2016 17, 789-796DOI: (10.1016/j.jamda.2016.04.019) Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine Terms and Conditions

Fig. 2 Effects of aging and illness on muscle mass. Journal of the American Medical Directors Association 2016 17, 789-796DOI: (10.1016/j.jamda.2016.04.019) Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine Terms and Conditions

Fig. 3 Complications of lean body mass (muscle) loss. Journal of the American Medical Directors Association 2016 17, 789-796DOI: (10.1016/j.jamda.2016.04.019) Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine Terms and Conditions

Fig. 4 Treatments for sarcopenia. It is currently recommended that patients at risk of or suffering from sarcopenia consume a diet high in protein, engage in resistance exercise, and take supplements of the leucine metabolite HMB. Journal of the American Medical Directors Association 2016 17, 789-796DOI: (10.1016/j.jamda.2016.04.019) Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine Terms and Conditions