Stimulation of α2Adrenoceptors Dilates the Rat Middle Cerebral Artery

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Stimulation of α2Adrenoceptors Dilates the Rat Middle Cerebral Artery Anesthes. 1996;85(1):82-90. Figure Legend: Figure 5. The effects of 10 sup -5 M N-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, on the dilation produced by UK14,304. The open symbols show the effects of L-NAME plus 10 sup -3 M L-arginine (L-arg), the substrate for nitric oxide synthase; or L-NAME plus 10 sup -3 M D-arginine (D-arg), the inactive isomer of L-arg, on the dilation produced by UK14,304. The closed symbols represent eight middle cerebral arteries and the open symbols represent eight middle cerebral arteries where two concentration-response curves were obtained for each middle cerebral artery. Diameters of the middle cerebral arteries: control 250+/-4 micro meter; after L-NAME 220+/-8 micro meter (P < 0.05 compared to control); after L-NAME + L-arg 245+/-8 micro meter; after L-NAME + D-arg 229+/-5 micro meter (P < 0.05 compared to L-NAME + L-arg). *P < 0.05 compared to control; #P < 0.05 compared to the L-NAME + L-arg group. Date of download: 11/9/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.