Bone metabolism in obese rats programmed by early weaning

Slides:

Advertisements

Similar presentations

Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

Advertisements

Chapter 7: Assessment of Bone Mass and Microarchitecture in Rodents Blaine A. Christiansen and Mary L. Bouxsein.

Carbohydrate and fat utilization during rest and physical activity Katarina Melzer European e-Journal of Clinical Nutrition and Metabolism Volume 6, Issue.

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Chapter 29: DXA in Adults and Children Judith Adams and Nick Bishop.

Umesh K. Narta, Shamsher S. Kanwar, Wamik Azmi

Date of download: 10/4/2017 Copyright © ASME. All rights reserved.

Predictors of abdominal obesity and high susceptibility of cardiometabolic risk to its increments among Turkish women: a prospective population-based.

Maternal protein restriction during pregnancy and lactation in rats imprints long-term reduction in hepatic lipid content selectively in the male offspring

The cortisol awakening response and the metabolic syndrome in a population-based sample of middle-aged men and women Inger Bengtsson, Lauren Lissner,

Insulin absorption: a major factor in apparent insulin resistance and the control of type 2 diabetes mellitus Samuel J. Friedberg, Yui-Wing Francis Lam,

Samuel Yeung Shan Wong, Dicken C.C. Chan, Athena Hong, Jean Woo

Volume 31, Issue 9, Pages (September 2015)

Effect of ovariectomy on BMD, micro-architecture and biomechanics of cortical and cancellous bones in a sheep model Zi-xiang Wu, Wei Lei, Yun-yu Hu,

Trans fat intake lowers total cholesterol and high-density lipoprotein cholesterol levels without changing insulin sensitivity index in Wistar rats Zhiliang.

Volume 32, Issue 7, Pages (July 2016)

Knee loading stimulates healing of mouse bone wounds in a femur neck

Volume 48, Issue 4, Pages (April 2011)

GLP-1 promotes angiogenesis in human endothelial cells in a dose-dependent manner, through the Akt, Src and PKC pathways Konstantinos N. Aronis, John.

Glucocorticoid-induced osteoporosis in the rat is prevented by the tyrosine phosphatase inhibitor, sodium orthovanadate P.A Hulley, M.M Conradie, C.R.

Volume 31, Issue 2, Pages (February 2011)

A short plate compression screw with diagonal bolts—A biomechanical evaluation performed experimentally and by numerical computation Eran Peleg, Rami.

Volume 26, Issue 3, Pages (March 2013)

Osteoporosis Diagnosis 9/21/2018 OSTEOPOROSIS.

I. Haider, A. Speirs, A. Alnabelseya, P.E. Beaulé, H. Frei

Osteoporosis in Individuals with Spinal Cord Injury

Erosion of lumbar vertebral bodies from a chronic contained rupture of an abdominal aortic pseudoaneurysm W. Andrew Oldenburg, MD, Tariq Almerey, MD

AgRP Neurons Regulate Bone Mass

Volume 127, Issue 3, Pages (September 2004)

Subchondral plate porosity colocalizes with the point of mechanical load during ambulation in a rat knee model of post-traumatic osteoarthritis H. Iijima,

Does Hypothalamic Inflammation Cause Obesity?

A Rare Cause of Multiple Bone Lesions: Metastasis or Not?

Deena Lala, Angela M. Cheung, Cheryl L

Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis S.K. Boyd, Ph.D., R. Müller, Ph.D.,

TB Determined: Tuberculous Osteomyelitis

Trabecular bone structure and spatial differences in articular cartilage MR relaxation times in individuals with posterior horn medial meniscal tears

Contrast-enhanced CT facilitates rapid, non-destructive assessment of cartilage and bone properties of the human metacarpal B.A. Lakin, D.J. Ellis, J.S.

Subchondral plate porosity colocalizes with the point of mechanical load during ambulation in a rat knee model of post-traumatic osteoarthritis H. Iijima,

Fuad M. Baroody, MD, Se-Hoon Suh, MD, Robert M. Naclerio, MD

Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice S. Hashimoto, M.F. Rai, K.L.

Mahmoud Mustafa Ali Abulmeaty Clinical Nutrition Experimental

Low magnitude high frequency vibration accelerated cartilage degeneration but improved epiphyseal bone formation in anterior cruciate ligament transect.

Exaggerated inflammatory environment decreases BMP-2/ACS-induced ectopic bone mass in a rat model: implications for clinical use of BMP-2 R.-L. Huang,

Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI.

Volume 11, Issue 3, Pages (March 2006)

P. Orth, M. Cucchiarini, S. Wagenpfeil, M.D. Menger, H. Madry

The chemokine receptor CCR5 plays a role in post-traumatic cartilage loss in mice, but does not affect synovium and bone K. Takebe, M.F. Rai, E.J. Schmidt,

Resveratrol increases serum adiponectin level and decreases leptin and insulin level in an experimental model of hypercholesterolemia A. Jimoh, Y. Tanko,

Vertebral Fracture Risk of Multiple Myeloma Assessed by a CT-based Finite Element and Trabecular Structure Analysis Miyuki Takasu, Yoko Kaichi, Kazuo.

Erosion of lumbar vertebral bodies from a chronic contained rupture of an abdominal aortic pseudoaneurysm W. Andrew Oldenburg, MD, Tariq Almerey, MD

Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice A. Cai, E. Hutchison,

Side effects of inhaled corticosteroids

Subchondral and epiphyseal bone remodeling following surgical transection and noninvasive rupture of the anterior cruciate ligament as models of post-traumatic.

Joint distraction attenuates osteoarthritis by reducing secondary inflammation, cartilage degeneration and subchondral bone aberrant change Y. Chen,

Relationships between in vivo dynamic knee joint loading, static alignment and tibial subchondral bone microarchitecture in end-stage knee osteoarthritis

Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus

Volume 11, Issue 3, Pages (March 2010)

In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model F. Intema, H.A.W.

The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral cores N.L.A. Fell, B.M. Lawless,

Micro-CT quantification of subchondral endplate changes in intervertebral disc degeneration J.P.H.J. Rutges, O.P. Jagt van der, F.C. Oner, A.J. Verbout,

Bone-Targeted Alkaline Phosphatase Treatment of Mandibular Bone and Teeth in Lethal Hypophosphatasia via an scAAV8 Vector Ryo Ikeue, Aki Nakamura-Takahashi,

Volume 4, Issue 1, Pages e4 (January 2017)

Antibiotic De-Escalation

Reduced bone mineral density in adults treated with high-dose corticosteroids for childhood nephrotic syndrome Janet Hegarty, M. Zulf Mughal, Judith.

P. Rahnamay Moshtagh, N. M. Korthagen, S. G. Plomp, B. Pouran, A

In vivo structural analysis of subchondral trabecular bone in osteoarthritis of the hip using multi-detector row CT K. Chiba, M. Ito, M. Osaki, M. Uetani,

Reduced bone formation in males and increased bone resorption in females drive bone loss in hemophilia A mice by M. Neale Weitzmann, Susanne Roser-Page,

mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss

Impact of Provider-led, Technology-enabled Radiology Management Program on Imaging Ivan K. Ip, MD, MPH, Louise Schneider, MD, Steven Seltzer, MD, Allen.

Volume 11, Pages (January 2019)

Presentation transcript:

Bone metabolism in obese rats programmed by early weaning Lígia de Albuquerque Maia, Patrícia Cristina Lisboa, Elaine de Oliveira, Natália da Silva Lima, Inaya Correa Barbosa Lima, Ricardo Tadeu Lopes, Leandro Dias Gonçalves Ruffoni, Keico Okino Nonaka, Egberto Gaspar de Moura Metabolism - Clinical and Experimental Volume 63, Issue 3, Pages 352-364 (March 2014) DOI: 10.1016/j.metabol.2013.11.010 Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 1 (a) Computed tomography image of femur, the region of interest is shown by R1 (femoral head); (b) Computed tomography image of lumbar vertebra, the region of interest is shown by R2 (vertebral body); (c) 3D representative microcomputed tomography image of the cylindrical region of interest (1.86mm of diameter) at the center of the femoral head showing the region of trabecular bone studied. Metabolism - Clinical and Experimental 2014 63, 352-364DOI: (10.1016/j.metabol.2013.11.010) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 2 Body weight after weaning until pups of 180days of control (•), mechanically early-weaned (■) and pharmacologically early weaned (▲).* MEW mean values were significantly different from those of C (P<0.05); †PEW mean values were significantly different from those of C (P<0.05), n=8. Metabolism - Clinical and Experimental 2014 63, 352-364DOI: (10.1016/j.metabol.2013.11.010) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 3 (a) Accumulated ingestion; (b) Feed efficiency at 180 days; (c) Visceral fat mass; (d) Serum leptin of control (C), mechanically early-weaned (MEW) and pharmacologically early weaned (PEW) offspring. Values are means, with their standard errors represented by vertical bars, n 8. *Mean values were significantly different from those of C (P<0.05). †Mean values were significantly different from those of MEW (P<0.05). Metabolism - Clinical and Experimental 2014 63, 352-364DOI: (10.1016/j.metabol.2013.11.010) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 4 (a) Total BMD; (b) Total BMC; (c) Spine BMD; (d) Bone Area of control (•), mechanically early-weaned (■) and pharmacologically early weaned (▲) offspring at different ages (90, 120, 150 and 180days). *Mean values were significantly different from those of control (P<0.05); †Mean values were significantly different from those of MEW (P<0.05). n=8 animals/group. Metabolism - Clinical and Experimental 2014 63, 352-364DOI: (10.1016/j.metabol.2013.11.010) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 5 (a) Femur BMD; (b) Fourth lumbar vertebra BMD; (c) Femoral head radiodensity; (d) Fourth lumbar vertebra vertebral body radiodensity at 180 days of control (C), mechanically early-weaned (MEW) and pharmacologically early weaned (PEW) offspring; (a) and (b) were evaluated by DXA and (c) and (d) were evaluated by CT. Values are means, with their standard errors represented by vertical bars. *Mean values were significantly different from those of C (P<0.05). †Mean values were significantly different from those of MEW (P<0.05). n=8 animals/group. Metabolism - Clinical and Experimental 2014 63, 352-364DOI: (10.1016/j.metabol.2013.11.010) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 6 (a) Bone volume fraction (BV/TV); (b) Trabecular Pattern Factor (Tb.Pf); (c) Trabecular Thickness (Tb.Th); (d) Trabecular Number (Tb.N); (e) Trabecular Separation (Tb.Sp) at 180days of control (C), mechanically early-weaned (MEW) and pharmacologically early weaned (PEW) offspring, evaluated by micro-CT. Values are means, with their standard errors represented by vertical bars. *Mean values were significantly different from those of C (P<0.05); †Mean values were significantly different from those of MEW (P<0.05). n=8 animals/group. Metabolism - Clinical and Experimental 2014 63, 352-364DOI: (10.1016/j.metabol.2013.11.010) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 7 (a) Maximal Deformation; (b) Stiffness; (c) Break Load; (d) Break Deformation at 180days of control (C), mechanically early-weaned (MEW) and pharmacologically early weaned (PEW) offspring, evaluated by three-point bending test. Values are means, with their standard errors represented by vertical bars. *Mean values were significantly different from those of C (P<0.05). n=8 animals/group. Metabolism - Clinical and Experimental 2014 63, 352-364DOI: (10.1016/j.metabol.2013.11.010) Copyright © 2014 Elsevier Inc. Terms and Conditions

Fig. 8 (a) CTX-I; (b) 25-Hydroxyvitamin D3 of control (C); mechanically early-weaned (MEW) and pharmacologically early-weaned (PEW) offspring. Values are means, with their standard errors represented by vertical bars. *Mean values were significantly different from those of C (P<0.05). n=8 animals/group. Metabolism - Clinical and Experimental 2014 63, 352-364DOI: (10.1016/j.metabol.2013.11.010) Copyright © 2014 Elsevier Inc. Terms and Conditions