Persistent secondary hyperparathyroidism after renal transplantation

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Presentation transcript:

Persistent secondary hyperparathyroidism after renal transplantation Piergiorgio Messa, Chiara Sindici, Giuseppe Cannella, Valeria Miotti, Andrea Risaliti, Maria Gropuzzo, Pier Luigi Di Loreto, Fabrizio Bresadola, Giuseppe Mioni Kidney International Volume 54, Issue 5, Pages 1704-1713 (November 1998) DOI: 10.1046/j.1523-1755.1998.00142.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Behavior of parathyroid hormone (PTH) after renal transplantation (RTx). The thicker line represents the behavior in the total number of patients; the two thinner lines represent respectively group A (lower line) and group B (upper line). PTH levels fell rapidly during the first three months and thereafter remained substantially stable (mean ± se;**P < 0.01 vs. basal values; the differences between the two groups were all statistically significant by definition).x Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Behavior of total serum calcium and phosphate in group A (thinner lines) and group B (thicker lines) in the follow-up period (mean ± se;x*P < 0.05 group A vs. group B). x Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Calcium-parathyroid hormone (PTH) sigmoidal relationship in RTx patients without (group A, left panel) and with persistent SHP (group B, right panel), compared with controls (C). In group B patients a shift of the curve to the right and upward, compared to the controls, is evident. Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Relationship between set point values and PTH basal levels in RTx patients (A) and the RP1 (○) and RP2 (•) (B). A direct linear relationship is evident in RTx patients (PTH = -406.5 + 384.8 × set point; r = 0.69, P < 0.001), but not in the other studied groups. Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1704-1713DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1704-1713DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1704-1713DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1704-1713DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1704-1713DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1704-1713DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1704-1713DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1704-1713DOI: (10.1046/j.1523-1755.1998.00142.x) Copyright © 1998 International Society of Nephrology Terms and Conditions