Anesthes. 1997;87(3): Figure Legend:

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From: Heparin-associated Thrombocytopenia and Thrombosis:Implications for Perioperative Management Anesthes. 1997;87(3):667-675. Figure Legend: Figure 1. Proposed mechanisms of thrombosis in HAT. Specific antibodies to the heparin/platelet factor 4 (PF4) complex generate immune complexes that bind to and activate platelets by way of Fc gamma RII receptors. Activated platelets release procoagulant microparticles, which provide a phospholipid surface to accelerate thrombin generation. In addition, heparin/PF4 immune complexes activate the extrinsic pathway of coagulation by binding to the vascular endothelial surface to induce localized expression of tissue factor. Date of download: 11/9/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.

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