Figure 3. Effect of LHRH-A (10<sup>−6</sup>m) on the IGF-I-induced tyrosine phosphorylation of the IGF-IR in DU 145 cells. LHRH-A was added to the experimental.

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Figure 3. Effect of LHRH-A (10<sup>−6</sup>m) on the IGF-I-induced tyrosine phosphorylation of the IGF-IR in DU 145 cells. LHRH-A was added to the experimental medium either 30 or 60 min before treatment with IGF-I (75 ng/ml). Lane 1, Controls without drug; lane 2, IGF-I (3 min); lane 3, LHRH-A (30 min); lane 4, LHRH-A (60 min); lane 5, IGF-I plus LHRH-A (30 min); lane 6, IGF-I plus LHRH-A (60 min). A, Representative Western immunoblot of the tyrosine-phosphorylated IGF-IR. B, Densitometric analysis of tyrosine phosphorylation of IGF-IR. The results are expressed as a percentage of the value of IGF-I induced tyrosine phosphorylation of IGF-IR and are the mean ± se of four separate experiments. Luteinizing Hormone-Releasing Hormone Agonists Interfere with the Mitogenic Activity of the Insulin-Like Growth Factor System in Androgen-Independent Prostate Cancer Cells**This work was supported by Associazione Italiana per la Ricerca sul Cancro, Consiglio Nazionale delle Ricerche through the special project ACRO (Contract 96.00594.PF39), and Ministero dell’Università e della Ricerca Scentifica e Tecnologica. Endocrinology. 1999;140(1):329-334. doi:10.1210/endo.140.1.6402 Endocrinology | Copyright © 1999 by The Endocrine Society 1