SWAG SSG Sarcoma Meeting Clinical Research Network West of England SWAG SSG Sarcoma Meeting Tuesday 31st January 2017

Clinical Research Network & Cancer Services West ofEngland SWAG - Somerset Wiltsire Avon & Gloucestershire South West Children’s Cancer & Leukaemia Research Network

NIHR CRN High Level Objectives Increase number of participants into NIHR CRN portfolio studies 650,000 in England 21,905 in West of England Increase the number of studies that deliver to time and target Target 80% Increase number of commercial studies delivered through network Reduce NHS study set up times Reduce time taken to recruit first participant

NIHR CRN Objectives for cancer Recruit 20% of cancer incidence West of England 1,909 Recruit 7.5% of cancer incidence into interventional studies 716 Include challenging studies Cancer surgery – 4 recruits per 100,000 population Radiotherapy – 6 recruits per 100,000 population Rare cancers (<6 per 100,000) – 12 recruits per 100,000 population Children & young people – 3 per 100,000 population Teenagers & young adults – record number of 16-25 year olds participating in research

Due to the complexity in classifying Sarcoma within the ICD-10 it was not possible to calculate recruitment as a % of Sarcoma incidence by LCRN. However according to Cancer Research UK (2014) figures for England as a whole, 5.8% of annual new registrations of Sarcoma were recruited into trials between April and December 2016.

Open studies in SWAG – Sarcoma NIHR ID Project Title Trust Principal Investigator BRAG Planned end date Recruited Target 19629 IMRiS: Phase II study of IMRT in primary bone and soft tissue sarcoma Gloucestershire Hospitals Candish, Dr Charlie -31.13% 04/03/2018 1 10 11721 STRASS: A phase III randomized study of preoperative radiotherapy plus surgery versus surgery alone for patients with Retroperitoneal sarcoma (RPS) University Hospitals Bristol Ayre, Dr Gareth -50.92% 09/01/2017 2 4 13804 Euro Ewing 2012 Rees, Dr Helen 50.96% 01/09/2024 3 17239 rEECur -14.71% 01/01/2020 8 BRAG Open studies Black Study not reported recruitment or study has not recruited Red % Recruitment is more than 30 behind % time elapsed, i.e. Difference < -30 Amber % Recruitment is less than 30 behind % elapsed time but more than 0 behind % elapsed time, i.e. -30 < Difference < 0 Green % Recruitment is equal to or greater than % elapsed time, i.e. Difference >= 0 Grey Unable to calculate RAG due to record missing at least one data point

Studies in set up – Sarcoma NIHR Study ID Title Trust Principal Investigator 19110 CANC - 4520 - A Phase 1/2 Study of FPA008 in patient with PVNS or dt-TGCT University Hospitals Bristol   19629 IMRiS: Phase II study of IMRT in primary bone and soft tissue sarcoma Ayre, Dr Gareth 30650 IDRIS

Useful links https://www.crn.nihr.ac.uk/ National and local network information including training programmes templates, tools, contacts, videos etc https://odp.nihr.ac.uk/ http:/ Open data platform. Look at performance across whole CRN including all specialty areas /csg.ncri.org.uk/portfolio/portfolio-maps/ View current national portfolio of open, closed and ‘in set up’ cancer studies https://www.ukctg.nihr.ac.uk/ See where a study is open across the country http://public-odp.nihr.ac.uk/  Search for a study to fit criteria. Good for horizon scanning, eligibility criteria

Contacts Research Delivery Manager – maxine.taylor@nihr.ac.uk Cancer portfolio facilitator – sarah.west@nihr.ac.uk Clinical Lead – adam.dangoor@uhbristol.nhs.uk