From: γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity Anesthes.

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From: γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity Anesthes. 2009;111(4):774-784. doi:10.1097/ALN.0b013e3181b55fae Figure Legend: Fig. 1. γ-Aminobutyric acid (GABA) concentration-response curves and etomidate left shifts. Each  panel  displays mean ± SD data for peak GABA-activated oocyte currents normalized to the maximum response.  Solid symbols  represent control data (no etomidate).  Open symbols  represent responses measured in the presence of 3.2 μm etomidate.  Lines  through data represent nonlinear least squares fits of data to logistic functions. Fitted parameters are reported in  table 1. Lower-right insets  in each panel display examples of current sweeps elicited with either 10 or 1,000 μm GABA in a single oocyte (  bars  above sweeps indicate application).  Upper left insets  in each panel display examples of current sweeps recorded from the same oocyte in the presence of etomidate. (  A  ) Wild-type α1β2γ2 l (  squares  ). Etomidate strongly potentiates currents at 10 μm GABA and induces a large leftward shift in GABA concentration-responses (14-fold reduction in EC50). (  B  ) α1β2(N265S)γ2 l (  circles  ). Etomidate weakly potentiates currents elicited with 10 μm GABA and induces a small leftward shift in GABA concentration-response (2.3-fold reduction in EC50); (  C  ) α1β2(N26 5m)γ2 l (  triangles  ). Etomidate does not enhance GABA-activated currents and does not significantly shift the GABA concentration-response curve.  Date of download: 11/10/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.

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