Tyler Dorrity Dr. DasMahapatra

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Presentation transcript:

Tyler Dorrity Dr. DasMahapatra Cancer Immunotherapy Tyler Dorrity Dr. DasMahapatra

Types of Immunity: Innate Nonspecific Physical and chemical barriers Inflammation PRR’s and PAMP’s Cytokines and pyroptosis Complement System

Types of Immunity: Innate Nonspecific Physical and chemical barriers Inflammation PRR’s and PAMP’s Cytokines and pyroptosis Complement System

Types of Immunity: Innate Nonspecific Physical and chemical barriers Inflammation PRR’s and PAMP’s Cytokines and pyroptosis Complement System

Types of Immunity: Innate Leukocytes Chemotaxis (Interleukin) and Phagocytosis Dendritic Cells Neutrophils (NETs and cytokines) Macrophages (M1, M2 and arginine) NK Cells “Self”, “Non-Self”, and “Missing Self” Cells MHC 1 and 2 Markers

Types of Immunity: Innate Leukocytes Chemotaxis (Interleukin) and Phagocytosis Dendritic Cells Neutrophils (NETs and cytokines) Macrophages (M1, M2 and arginine) NK Cells “Self”, “Non-Self”, and “Missing Self” Cells MHC 1 and 2 Markers

Types of Immunity: Adaptive Specific (Vertebrates only) Lymphocytes B Cells Memory and Plasma T Cells Helper and Memory Cytotoxic and NKT

Types of Immunity: Adaptive Specific (Vertebrates only) Lymphocytes B Cells Memory and Plasma T Cells Helper and Memory Cytotoxic and NKT

Types of Immunity: Adaptive Specific (Vertebrates only) Lymphocytes B Cells Memory and Plasma T Cells Helper and Memory Cytotoxic and NKT

How does this relate to cancer treatments?

Types of Cancer Immunotherapy Cytokine Therapy Dendritic Cell Vaccines In or ex vivo Targeted Therapies Monoclonal Antibodies (MAb)

Types of Cancer Immunotherapy Cytokine Therapy Dendritic Cell Vaccines In or ex vivo Targeted Therapies Monoclonal Antibodies (MAb)

Types of Cancer Immunotherapy Cytokine Therapy Dendritic Cell Vaccines In or ex vivo Targeted Therapies Monoclonal Antibodies (MAb)

Immune Checkpoints PD-L1 Pathway Slows immune propagation Interference with PD-L2

Immune Checkpoints PD-L1 Pathway Slows immune propagation Interference with PD-L2

Immune Checkpoints PD-L1 Pathway Slows immune propagation Interference with PD-L2

Thank You Any questions?