Diaphragmatic length–tension curve in normal hamsters and hamsters with elastase-induced emphysema. Tension is expressed as a percentage of maximum tetanic.

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Presentation transcript:

Diaphragmatic length–tension curve in normal hamsters and hamsters with elastase-induced emphysema. Tension is expressed as a percentage of maximum tetanic tension, PO, and length is expressed as a percentage of original optimal length, LO. The degree of filament overlap among actin (A) and myosin (M) filaments in control (A), acute (B), and chronic hyperinflation (C) is shown. Note that due to sarcomere adaptation in chronic hyperinflation, the degree of filament overlap is the same at a considerably shorter length. (Reproduced with permission from Farkas G: Functional characteristics of the respiratory muscles. Sem Respir Crit Care Med. 1991;12(4):247–257.) Source: The Respiratory Muscles, Fishman's Pulmonary Diseases and Disorders, 5e Citation: Grippi MA, Elias JA, Fishman JA, Kotloff RM, Pack AI, Senior RM, Siegel MD. Fishman's Pulmonary Diseases and Disorders, 5e; 2015 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/1344/p9780071796729-ch003_f002.png&sec=111827975&BookID=1344&ChapterSecID=72260864&imagename= Accessed: November 10, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved