Copyright © 2015 by the American Osteopathic Association. From: Lymphatic Drainage of the Neuraxis in Chronic Fatigue Syndrome: A Hypothetical Model for the Cranial Rhythmic Impulse J Am Osteopath Assoc. 2007;107(6):218-224. doi:10.7556/jaoa.2007.107.6.218 Figure Legend: Cerebrospinal fluid drains from the human brain in three main pathways: into the sinus arachnoid villi, down the spine into the paravertebral lymphatics, and along the cranial nerves (I, olfactory; II, optic; V, trigeminal; VIII, vestibulocochlear). The cerebrospinal fluid then flows into the facial, cervical, and thoracic lymphatics. Reprinted with permission from: Knopf PM, Cserr HF, Nolan SC, Wu TY, Harling-Berg CJ. Physiology and immunology of lymphatic drainage of interstitial and cerebrospinal fluid from the brain. Neuropathol Appl Neurobiol. 1995;21:175-180, Blackwell Publishing. Date of download: 11/10/2017 Copyright © 2015 by the American Osteopathic Association. All rights reserved.