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Copyright © 2015 by the American Osteopathic Association. From: Opioid-Induced Endocrinopathy J Am Osteopath Assoc. 2009;109(1):20-25. doi:10.7556/jaoa.2009.109.1.20 Figure Legend: The hypothalamic-pituitary-gonadal axis controls the production and secretion of sex hormones. Gonadotropin-releasing hormone (GnRH) is released by the hypothalamus and stimulates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones cause the testes to secrete testosterone and the ovaries to release estrogen. As testosterone and estrogen levels rise, the hypothalamus produces less GnRH. Date of download: 11/10/2017 Copyright © 2015 by the American Osteopathic Association. All rights reserved.

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