Antibodies to the GluN1 subunit of the N-methyl-d-aspartate (NMDA) receptor in a patient with anti-NMDA receptor encephalitis and ovarian teratoma. (A)

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Presentation transcript:

Antibodies to the GluN1 subunit of the N-methyl-d-aspartate (NMDA) receptor in a patient with anti-NMDA receptor encephalitis and ovarian teratoma. (A) Coronal section of rat brain immunolabeled (green fluorescence) with the patient’s antibodies. The reactivity predominates in the hippocampus, which is highly enriched in NMDA receptors. (B) This image shows the antibody reactivity with cultures of rat hippocampal neurons; the intense green immunolabeling is due to the antibodies against the GluN1 subunit of NMDA receptors. (C–E) Images of HEK cells (a human kidney cell line) transfected to express NMDA receptors, showing reactivity with patient’s antibodies (C) and with a commercial monoclonal antibody against NMDA receptors (E); the patient’s antibody reactivity co-labels only the cells that express NMDA receptors (D). (From J Dalmau et al: Lancet Neurol 7:1091, 2008; with permission.) Source: PARANEOPLASTIC NEUROLOGIC SYNDROMES AND AUTOIMMUNE ENCEPHALITIS, Harrison's Neurology in Clinical Medicine, 4e Citation: Hauser SL, Josephson S. Harrison's Neurology in Clinical Medicine, 4e; 2017 Available at: http://neurology.mhmedical.com/DownloadImage.aspx?image=/data/books/2207/hauserneuro4_ch50_f001-1.png&sec=169311436&BookID=2207&ChapterSecID=169311427&imagename= Accessed: November 10, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved