Tissue/Organ Engineering

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Presentation transcript:

Tissue/Organ Engineering What will be covered. Types of cells Scaffolds Biocompatibility

122,572 8,030 How can this be useful? Heart Disease 6,000,000 550,000 Pulmonary Disease (COPD) 12,000,000 Renal Failure 530,000 Heart – 0.6 Lung – 2.5 Kidney – 3.3 122,572 8,030

What is tissue engineering?

What kinds of cells are used? Specialized cells How do we obtain them? Stem Cells: Embryonic Vs. Placental/Umbilical Use the patient’s cells

What methods are used to create scaffolds? Things to consider Biocompatibility Vascularization Biodegradability Decellularization ECM Allows for vascularization Allows for optimal biocompatibility A “natural” scaffold

Summary This is still a developing technology. The best method of scaffolding is using the process of decellularization, but there are others. Stem cells can also be used to allow cells to grow and specialize.

Works Cited Meul. CoeurHumain. Digital image. Commons Wikimedia. N.p., 22 Jan. 2008. Web. <https://commons.wikimedia.org/wiki/File:CoeurHumain.svg>. "Organ Matching Process." Organdonor.gov. N.p., n.d. Web. 26 Sept. 2015. "Tissue Engineering." Wikipedia. Wikimedia Foundation, n.d. Web. 26 Sept. 2015. "Decellularization." Wikipedia. Wikimedia Foundation, n.d. Web. 26 Sept. 2015. Baptista, Pedro M. “The Use of Whole Organ Decellularization for the Generation of a Vascularized Liver Organoid.” Hepatology 53.2 (2011): 604-617. Print "About Us." <http://ottlab.mgh.harvard.edu/?page_id=2>. “The ABCs of Organ Engineering” http://www.wakehealth.edu/Research/WFIRM/Our-Story/Inside-the- Lab/Inside-the-Lab.htm “Tissue Engneering: How to build a heart” http://www.nature.com/news/tissue-engineering-how-to-build-a- heart-1.13327 “Vacanti mouse” <https://en.wikipedia.org/wiki/Vacanti_mouse>