Poliomyelitis Chris Berry

Polio is a childhood disease that was endemic until the 1880s Information – http://www.who.int/mediacentre/factsheets/fs114/en/ http://en.wikipedia.org/wiki/Polio Photos – http://2.bp.blogspot.com/_ChxfFH9ehDU/SxUHfEju4sI/AAAAAAAAAao/L3RiZNinVWA/s1600/polio_symptoms.jpg http://1.bp.blogspot.com/-SV6TjnV4qY8/Tn7qkl5A82I/AAAAAAAABMM/FaXl6RsDHhU/s1600/Poliomyelitis+%2528Polio%2529++patients.jpg

Polio is transmitted by the oral-oral or fecal-oral route Information - http://polio.emedtv.com/polio/polio-transmission.html Photo - http://www.lightstalkers.org/images/show/748242

The “discovery” of polio occurred in two steps Michael Underwood (1789) Jakob Heine (1840) Information - http://en.wikipedia.org/wiki/Poliomyelitis Photos - http://en.wikipedia.org/wiki/Jakob_Heine

Karl Landsteiner, Erwin Poppin identified the virus that causes Polio in 1908 Information - http://en.wikipedia.org/wiki/Poliomyelitis Photo - http://en.wikipedia.org/wiki/Karl_Landsteiner

Polio is a human enterovirus Information - http://en.wikipedia.org/wiki/Poliovirus Photos - http://americanhistory.si.edu/polio/virusvaccine/how.htm http://bilbo.bio.purdue.edu/~baker/projects/picorna/polio/polio.html

Viral Genome Capsid proteins RNA dependent RNA polymerase Information and Photo - http://en.wikipedia.org/wiki/Poliovirus RNA dependent RNA polymerase Capsid proteins Proteins complex viral replication Binds viral RNA, synthesis of + and – RNA proteases

The polio virus will leave the cell 4-6 hours after full assembly 5-35 day incubation Information and photo - http://en.wikipedia.org/wiki/Poliovirus

95% of all polio cases are subclinical Information - http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002375/ Photo - http://www.doctortipster.com/462-uderstanding-fever-and-how-to-treat-it.html

Clinical non-paralytic cases typically last 1-2 weeks Information - http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002375/ Photos- http://www.nytimes.com/slideshow/2008/11/03/health/110408-Dengue_5.html http://why-take-fish-oil-supplements.com/fight-the-signs-and-symptoms-of-inflammation-with-omega-3-supplements/why-is-inflammation-bad/ http://wastetimepost.com/afca766a0d1/your%20back%20pain http://www.sciencephoto.com/image/269316/530wm/M3820104-Neck_pain_hands_of_a_woman_holding_her_neck-SPL.jpg

Paralytic clinical infections occur less than1% of the time Information - http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002375/ Photo – http://pathmicro.med.sc.edu/lecture/images/polioboy.jpg http://www.vaccineinformation.org/photos/poliwho002.jpg

There is no cure for Polio Information – http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002375/ Photos - http://www.disease-disease.com/poliomyelitis http://www.washingtonpost.com/2012/01/12/gIQA74jQtP_photo.html

Prevention is the key Jonas Salk creates first vaccine (1952) Injected inactivated virus Information - http://en.wikipedia.org/wiki/Polio_vaccine Photo - http://poliovaccine.umwblogs.org/files/2011/03/salk-newspaper2.jpg

Prevention is the key Jonas Salk creates first vaccine (1952) Injected inactivated virus Albert Sabin creates second vaccine (1957) Oral attenuated virus Information - http://en.wikipedia.org/wiki/Polio_vaccine Photos – http://poliovaccine.umwblogs.org/files/2011/03/salk-newspaper2.jpg http://www.wired.com/images_blogs/thisdayintech/2011/10/sabin_350px.jpg

In 1988 there were over 350,000 cases in over 125 endemic countries Information - http://www.who.int/mediacentre/factsheets/fs114/en/ Photo - http://www.who.int/features/2004/polio/en/#

To the Rescue Global Polio Eradication Initiative (1988) Information - http://www.who.int/mediacentre/factsheets/fs114/en/ Photos - http://www.who.int/en/ http://www.rotary.org/en/Pages/ridefault.aspx http://www.cdc.gov/ http://www.unicef.org/

Troubles Arise

More than 351 million children from 40 different countries were immunized in 2009 Information - http://www.who.int/mediacentre/factsheets/fs114/en/ Photos - http://en.wikipedia.org/wiki/Polio_vaccine

There were only 1,352 cases worldwide as of 2010 Total Cases Year-to-date 2012 Year-to-date 2011 Total in 2011 Globally 25 55 650 -in endemic countries 24 18 341 -in non-endemic countries 1 37 79 Table - http://www.polioeradication.org/Dataandmonitoring/Poliothisweek.aspx

Photo - http://www. polioeradication

Information- http://www.polioeradication.org/Infectedcountries.aspx Photo - http://www.polioeradication.org/Dataandmonitoring.aspx

References WHO, Poliomyelitis Facts Sheet Wikipedia, Polio http://www.who.int/mediacentre/factsheets/fs114/en/ Wikipedia, Polio http://en.wikipedia.org/wiki/Polio MedTV, Polio Transmission http://polio.emedtv.com/polio/polio-transmission.html Wikipedia, Poliomyelitis http://en.wikipedia.org/wiki/Poliomyelitis Wikipedia, Poliovirus http://en.wikipedia.org/wiki/Poliovirus Pub Med Health, Poliomyelitis http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002375/ Aylward, R.B. Eradicating Polio: today’s challenges and tomorrow’s legacy. Global Polio Eradication Initiative, Data http://www.polioeradication.org/Dataandmonitoring/Poliothisweek.aspx Global Polio Eradication Initiative, Infected Countries http://www.polioeradication.org/Infectedcountries.aspx