Diagnosing peanut allergy with skin prick and specific IgE testing

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Presentation transcript:

Diagnosing peanut allergy with skin prick and specific IgE testing Graham Roberts, DM, Gideon Lack, FRCPCH, the Avon Longitudinal Study of Parents and Children Study Team Journal of Allergy and Clinical Immunology Volume 115, Issue 6, Pages 1291-1296 (June 2005) DOI: 10.1016/j.jaci.2005.02.038 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Predicted relationship between skin prick test result and challenge for peanuts. The logistic regression coefficient was 0.615 (95% CI, 0.411 to 0.818) and constant −1.60 (95% CI, −2.19 to −1.01). The area under the receiver operator curve was 0.86. Journal of Allergy and Clinical Immunology 2005 115, 1291-1296DOI: (10.1016/j.jaci.2005.02.038) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Predicted relationship between specific IgE and challenge for peanuts. The logistic regression coefficient was 0.521 (95% CI, 0.328 to 0.713) and constant 0.209 (95% CI, −0.163 to 0.581). The area under the receiver operator curve was 0.77. Journal of Allergy and Clinical Immunology 2005 115, 1291-1296DOI: (10.1016/j.jaci.2005.02.038) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Normogram for generating posttest probabilities from likelihood ratios. The use of likelihood ratios is demonstrated by 2 clinical examples. Copyright © 1975 Massachusetts Medical Society. Adapted 2005 with permission from Fagan TJ. Nomogram for Bayes's theorem. N Engl J Med 1975;293:257. Journal of Allergy and Clinical Immunology 2005 115, 1291-1296DOI: (10.1016/j.jaci.2005.02.038) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions