From: Propofol Affects Neurodegeneration and Neurogenesis by Regulation of Autophagy via Effects on Intracellular Calcium Homeostasis Anesthes. 2017;127(3):490-501.

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From: Propofol Affects Neurodegeneration and Neurogenesis by Regulation of Autophagy via Effects on Intracellular Calcium Homeostasis Anesthes. 2017;127(3):490-501. doi:10.1097/ALN.0000000000001730 Figure Legend: Propofol affects neural progenitor cell differentiation via inositol 1,4,5-trisphosphate receptors. (A) Representative micrographs showing immunostaining for Tuj1, neuronal class III β-tubulin (red), glial fibrillary acidic protein (GFAP; green), and 4′,6-diamino-2-phenylindole (DAPI; blue) of ReNcell neural progenitor cells cultured in differentiation medium for 3 days. (B) Representative micrographs showing immunostaining of Tuj1 (red), GFAP (green), and DAPI (blue) of neural progenitor cells cultured with 10 or 200 μM propofol, with or without the inositol 1,4,5-trisphosphate receptor antagonist, xestospongin C (Xc; 50 nm), followed by differentiation medium for 3 days. (C, D) Tuj1-positive (C) or GFAP-positive (D) cells were counted, and the data expressed are as percentages of controls. Propofol at 10 μM increased Tuj1-positive neuronal cells but decreased the GFAP-positive glial cells. Propofol at 200 μM had the opposite effect of deceasing Tuj1-positive cells and increasing GFAP-positive cells. These effects could be mitigated by cotreatment with Xc. Scale bar = 50 μm. The data are expressed as the mean ± SD and analyzed by one-way ANOVA followed by Tukey multiple comparison tests. **P < 0.01, ***P < 0.001, ****P < 0.0001. Date of download: 11/10/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.