Deyong Lv 1, 2, 3 ;Jingbo Li 4 ;Hongfu Li 3 ;Yu Fu 5 ;Wei Wang 1, 2 ; Imaging and Quantitative Analysis of the Interstitial Space in the Caudate Nucleus in a Rotenone-Induced Rat Model of Parkinson#cod#x02019;s Disease Using Tracer-based MRI Deyong Lv 1, 2, 3 ;Jingbo Li 4 ;Hongfu Li 3 ;Yu Fu 5 ;Wei Wang 1, 2 ; 1 Department of Radiology, Peking University Third Hospital, Beijing 100191, China ; 2 Beijing Key Laboratory of Magnetic Resonance Imaging Device and Technique, Beijing 100191, China ; 3 Department of Radiology, Dongying People#cod#x02019;s Hospital of Shandong, Shandong, 257091, China ; 4 Department of Ultrasound, Dongying People#cod#x02019;s Hospital of Shandong, Shandong, 257091, China ; 5 Department of Neurology, Peking University Third Hospital, Beijing 100191, China ; Figure 3. Alterations in the microstructure parameters D#cod#x0002A;, #cod#x003BB; and the clearance of Gd-DTPA k #cod#x02019;, t #cod#x000BD; in the caudate nucleus after rotenone-induced damage and madopar treatment . A Compared to the sham group, the effective diffusion parameterD#cod#x0002A; was significantly increased in the rotenone-induced group. No differences were observed between the sham group and the madopar-treated group. B Compared to the sham group, tortuosity #cod#x003BB; was significantly decreased in the rotenone-induced group. No differences were observed between the sham group and the madopar-treated group. C Compared to the sham group, the clearance rate constant k #cod#x02019; was significantly decreased in the rotenone-induced group. No differences were observed between the sham group and the madopar-treated group. D Compared to the sham group, half-life t #cod#x000BD; was significantly prolonged in the rotenone-induced group. No differences were observed between the sham group and the madopar-treated group. Data are the mean #cod#x000B1; SEM n=10; SNK test was performed. #cod#x0002A; represents P #cod#x0003C;0.05 Aging and Disease,null,8(1),1-6. Doi:10.14336/AD.2016.0625