Figure 1 Protective effects of acellular pertussis vaccines (A–F) in the respiratory infection model. Mice were challenged by exposure to an aerosol of.

Slides:



Advertisements
Similar presentations
Preclinical evaluation of safety, efficacy, immunogenicity of a recombinant rBCG Pasteur B vaccine Group B4 March 16, 2011 Adane Miheret, Tewodros Tariku.
Advertisements

Fig. 1. Antibody response in mice immunized with VLP. Three groups of mice (n=10/group) were used in this study. Mice in groups 1 and 2 were immunized.
1 Progress Report 2/04/2009 TVDC team – UNM Prepared by Terry Wu & Amanda DuBois.
Dual effects of vitamin D–induced alteration of TH1/TH2 cytokine expression  Victor Matheu, MD, Ove Bäck, MD, PhD, Emma Mondoc, BSc, Shohreh Issazadeh-Navikas,
Molecular Therapy - Methods & Clinical Development
The association between anti-PcrV titers and protective effects against P. aeruginosa in PcrV vaccinated mice Saeko Hamaoka1, Yoshifumi Naito1, Hideya.
From: Bioleaching: metal solubilization by microorganisms
Figure 4 Lack of protective effects of dietary supplementation with non-aggregating mutant L. crispatus MU5 on DSS colitis. DSS colitis was induced as.
4 A correlation between citrulline excretion and cell lysis by resting cells of L. buchneri CUC-3 in tartrate buffer (pH 3.6) without added arginine, citrulline.
Figure 3 Graph shows the percent reduction of [3H]thymidine incorporation of mitogen- or antigen-stimulated PBL proliferation by OspA prepared.
Figure 2 Effect of protease inhibitors added incubated 1 h at room temperature on biomarker detection in whole saliva. Results are expressed as mean channel.
Fig. 3. Activation and Th1 differentiation of the P25 TCR-Tg CD4+ T cells after BCG lung infection. The N-P25 TCR-Tg mice were i.t.
Fig. 1. Time course of total cells, protein concentration and cytokines in BAL fluid after LPS challenge. The number of total cells, neutrophils and macrophages.
Figure 5 Transferrin saturation, NTBI and bacterial growth in the serum of three stem cell transplantation patients, of whom one (A) did not receive apotransferrin.
Fig. 4. Activation of type‐1‐dependent antitumor cellular immunity by repeated DC1/Th1 tumor‐vaccine cell therapy in tumor‐bearing mice. (A)
Volume 5, Issue 1, Pages (January 2009)
The Panton–Valentine leukocidin vaccine protects mice against lung and skin infections caused by Staphylococcus aureus USA300  E.L. Brown, O. Dumitrescu,
Delivery of antigen to nasal-associated lymphoid tissue microfold cells through secretory IgA targeting local dendritic cells confers protective immunity 
Complexes of trophoblastic peptides and heat shock protein 70 as a novel contraceptive vaccine in a mouse model  Mei Han, Yuan Yao, Wangjiang Zeng, Yanfang.
Chiara Martinoli, Andrea Chiavelli, Maria Rescigno  Immunity 
Immunologic Characterization of HIV-Specific DNA Vaccine
Interleukin 6 mediates selected effects of Notch in chondrocytes
Volume 15, Issue 2, Pages (February 2007)
Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation  Yuki Nakamura,
IL-21 Reduces Immediate Hypersensitivity Reactions in Mouse Skin by Suppressing Mast Cell Activation or IgE Production  Risa Tamagawa-Mineoka, Tsunao.
by Éric Aubin, Réal Lemieux, and Renée Bazin
Increased levels of immunological markers in the respiratory tract but not in serum correlate with active pulmonary mycobacterial infection in mice  J.
Volume 16, Issue 2, Pages (February 2002)
Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a by Kayoko Sato, Yasuyuki Imai,
Volume 6, Issue 2, Pages (August 2009)
Volume 137, Issue 5, Pages e1 (November 2009)
Volume 22, Issue 7, Pages (July 2014)
Dominique Velin, Daniel Bachmann, Hanifa Bouzourene, Pierre Michetti 
Volume 124, Issue 3, Pages (March 2003)
Volume 141, Issue 4, Pages e1 (October 2011)
Impacts of interleukin-12 on multiplication of Mycobacterium tuberculosis and Mycobacterium avium complex in mice  Nacer Lounis, Baohong Ji, Chantal Truffat-Pernot,
Pathophysiology of in-vitro induced filaments, spheroplasts and rod-shaped bacteria in neutropenic mice  J. Buijs, A.S.M. Dofferhoff, J.W. Mouton, J.W.M.
Prevention of Genital Herpes Simplex Virus Type 1 and 2 Disease in Mice Immunized with a gD-Expressing Dominant-Negative Recombinant HSV-1  Richard Brans,
Immunization with a DNA vaccine of testis-specific sodium-hydrogen exchanger by oral feeding or nasal instillation reduces fertility in female mice  Tao.
FMDV-specific IgG, IgG1, and IgG2 in sera of guinea pigs (n = 6/group) immunized on days 1 and 21 by intramuscular injection of FMDV antigens (type O)
Volume 6, Issue 4, Pages (April 1997)
Vaccination of Mice Against H pylori Induces a Strong Th-17 Response and Immunity That Is Neutrophil Dependent  Elizabeth S. DeLyria, Raymond W. Redline,
Volume 31, Issue 2, Pages (August 2009)
Volume 115, Issue 4, Pages (October 1998)
Impaired Development of Th2 Cells in IL-13-Deficient Mice
FMD VP1-specific IgG, IgG1, and IgG2 in sera of guinea pigs (n = 6/group) immunized on days 1 and 21 by intramuscular injection of FMDV antigens (type.
Detection of CSFV-specific antibodies in immunized/challenged pigs using blocking ELISA. Groups of pigs (n = 5) were inoculated with different doses of.
CpG Oligodeoxynucleotides Prevent the Development of Scleroderma-Like Syndrome in Tight-Skin Mice by Stimulating a Th1 Immune Response  Yan Shen, Motohide.
Volume 33, Issue 1, Pages (July 2010)
Volume 15, Issue 2, Pages (February 2007)
Mukesh Kumar, PhDa, Aruna K. Behera, PhDa, Jianan Hu, MDa, Richard F
Impaired Development of Th2 Cells in IL-13-Deficient Mice
Volume 5, Issue 1, Pages (January 2009)
CD40, but Not CD40L, Is Required for the Optimal Priming of T Cells and Control of Aerosol M. tuberculosis Infection  Vanja Lazarevic, Amy J Myers, Charles.
Cyclooxygenase-2 Inhibition Promotes Enhancement of Antitumor Responses by Transcutaneous Vaccination with Cytosine-Phosphate-Guanosine- Oligodeoxynucleotides.
IFN-τ inhibits IgE production in a murine model of allergy and in an IgE-producing human myeloma cell line  Mustafa G. Mujtaba, PhDa, Lorelie Villarete,
Repeated Topical Challenge with Chemical Antigen Elicits Sustained Dermatitis in NC/Nga Mice in Specific-Pathogen-Free Condition  Yoshiaki Tomimori, Yoshitaka.
Antigen-Specific Suppression of a Primed Immune Response by Dendritic Cells Mediated by Regulatory T Cells Secreting Interleukin-10  Ela Martin, Brendan.
MP cells can mediate resistance in infectious models that induce TH1-type immunity. MP cells can mediate resistance in infectious models that induce TH1-type.
AN12855 is efficacious in acute and chronic murine models of TB infection. AN12855 is efficacious in acute and chronic murine models of TB infection. (A,
Volume 7, Issue 3, Pages (September 1997)
Viswanath P. Kurup, PhDa, Brian W. P
Volume 41, Issue 4, Pages (October 2014)
Prime and boosts with PBK001 vaccine provided 100% protection with low bacterial burden in organs. Prime and boosts with PBK001 vaccine provided 100% protection.
Forest plot of clinical trials reporting efficacy of acellular and whole-cell pertussis vaccines (38, 404, 590 – 593). Forest plot of clinical trials reporting.
Both the MMP9 and MMP2 systems are activated by anti-Aβ antibodies, IVIg, and mouse IgG. Both the MMP9 and MMP2 systems are activated by anti-Aβ antibodies,
CD4+ cells are required to generate protective immunity against the MT-HA tumor in HA104 mice. CD4+ cells are required to generate protective immunity.
Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice  Jürgen.
Antigen-specific cytokine-producing cells (IFN-γ and IL-5) detected by ELISPOT assay 3 weeks after the 3rd immunization. Antigen-specific cytokine-producing.
Distribution of responses to vaccine antigens in the culture-positive individual group and the control group. Distribution of responses to vaccine antigens.
Presentation transcript:

Figure 1 Protective effects of acellular pertussis vaccines (A–F) in the respiratory infection model. Mice were challenged by exposure to an aerosol of B. pertussis strain 18–323. Mouse lungs were removed 14 days after the challenge and bacteria in the lungs were counted. Results are presented as CFU, and are mean values per lung, as estimated from individual lungs of five mice. STD, standard pertussis vaccine (whole-cell pertussis vaccine). Each column with a vertical line represents a mean and standard error. *P<0.05 versus the control group. From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3):219-225. doi:10.1111/j.1574-695X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

Figure 2 Protective effects of acellular pertussis vaccines in the intracerebral challenge model. Mice were challenged, 21 days after immunization, with B. pertussis strain 18–323 which was introduced intracerebrally. The mice were observed for 14 days (see Section 2 for details). STD, standard pertussis vaccine (whole-cell pertussis vaccine). From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3):219-225. doi:10.1111/j.1574-695X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

Figure 3 Correlation between clearance of bacteria from the lungs after aerosol challenge of immunized mice (one immunization) and the potency of vaccines as determined by i.c. challenge. From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3):219-225. doi:10.1111/j.1574-695X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

Figure 4 Levels of antigen-specific IgG in the serum of immunized mice Figure 4 Levels of antigen-specific IgG in the serum of immunized mice. Sera from control mice (Saline) and immunized mice (A–F and STD) were examined by ELISA. Levels of antibodies (anti-PT, anti-FHA, anti-PRN and anti-Fim) were expressed as EU ml<sup>−1</sup>. Each column with a vertical line represents the mean and standard error of results from individual samples of serum from five mice in each group. STD, standard pertussis vaccine (whole-cell pertussis vaccine). From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3):219-225. doi:10.1111/j.1574-695X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

Figure 5 Secretion of IFN-γ by spleen cells in vitro in response to vaccine components as antigens. Spleen cells were prepared from control mice (Saline) and immunized mice (A–F and STD). The results represent mean concentrations of IFN-γ, as estimated from individual cultures of spleen cells from five mice in each group. Each column with a vertical line represents a mean and standard error of results from individual samples of spleen cells from five mice in each group. STD, standard pertussis vaccine (whole-cell pertussis vaccine). From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3):219-225. doi:10.1111/j.1574-695X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.

Figure 6 Secretion of IL-4 by spleen cells in vitro in response to vaccine components as antigens. See legend to Fig. 5 for details. From: Evaluation of efficacy in terms of antibody levels and cell-mediated immunity of acellular pertussis vaccines in a murine model of respiratory infection FEMS Immunol Med Microbiol. 2002;33(3):219-225. doi:10.1111/j.1574-695X.2002.tb00594.x FEMS Immunol Med Microbiol | © 2002 Federation of European Microbiological Societies.