Collagen By: Maryam Behmanesh

making up from 25% to 35% of the whole-body protein content Collagen : The main structural protein in the extracellular space in the various connective tissues in animal bodies. making up from 25% to 35% of the whole-body protein content collagen tissues may be rigid (bone), compliant (tendon), or have a gradient from rigid to compliant (cartilage)

Collagen, in the form of elongated fibrils, is mostly found in : Tendons Ligaments Skin Corneas Cartilage Bones Blood Vessels Gut Intervertebral discs Dentin in teeth Collagen, in the form of elongated fibrils, is mostly found in :

Types of collagen Fibrillar Non-fibrillar (Type I, II, III, V, XI) Non-fibrillar FACIT: (Fibril Associated Collagens with Interrupted Triple Helixes) Short chain Basement membrane Multiplexin(Multiple Triple Helix domains with Interruptions) MACIT (Membrane Associated Collagens with Interrupted Triple Helices) Other

The five most common types are: Type I: skin, tendon, vascular ligature, organs, bone  (main component of the organic part of bone) Type II: cartilage (main collagenous component of cartilage) Type III: reticulate (main component of reticular fibers,commonly found alongside type I.) Type IV: forms basal lamina, the epithelium-secreted layer of the basement membrane. Type V: cell surfaces, hair and placenta

Fig1: Proline hydroxylation of oxygen assisted by Prulyl hydroxylase enzyme and vitamin C (ascorbate(

Fig2: Carbohydrate units in the building of collagen

Fig3: The formation of collagen by procollagen sequence into Tropo procollagen peptidase enzymes.

Fig4: How to get Tropocollagen fields

Fig5:Bandolly production and R Lyzynonor between two lysine and leucine Tropo procollagen connection to each other.

Fig6: The synthesis steps os collagen Synthesized polypeptide sequence Hydrocsillation of Prolin & Lysine Gllicozilation of Lysine Production of procollagen

Diseases Epidermolysis bullosa junctional Epidermolysis bullosa Motation in XVII collagen Defective collagen type VII

Ehlers–Danlos syndrome

Real-time atomic force microscopy imaging of collagen fibril under ultraviolet irradiation [Young-Sang Youn,Sehun Kim(2016)]

Metalloproteinase

Collagen products maker