From: Inhalational Anesthetics Disrupt Postsynaptic Density Protein-95, Drosophila Disc Large Tumor Suppressor, and Zonula Occludens-1 Domain Protein Interactions.

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From: Inhalational Anesthetics Disrupt Postsynaptic Density Protein-95, Drosophila Disc Large Tumor Suppressor, and Zonula Occludens-1 Domain Protein Interactions Critical to Action of Several Excitatory Receptor Channels Related to Anesthesia Anesthes. 2015;122(4):776-786. doi:10.1097/ALN.0000000000000609 Figure Legend: Halothane and isoflurane dose-dependently disrupt the association between postsynaptic density protein-95 (PSD-95) and potassium channel Kv1.4 in the forebrain. (A) The glutathione S-transferase (GST) pull-down assay showed that halothane dose-dependently inhibits the interaction between PSD-95 PDZ2 and Kv1.4 C-terminus. The bottom panelsindicate equal amounts of loading of GST fusion proteins. (B) The coimmunoprecipitation assay showed that isoflurane dose-dependently disrupts the association between PSD-95/SAP90 and Kv1.4 in vivo. The specificity of the anti-Kv1.4 antibody was verified by preincubation with Kv1.4 fusion peptide (N). As a positive control (input), 40 μg of the solubilized membrane proteins were loaded onto the gel. IB = immunoblotting; IP = immunoprecipitation; PDZ = postsynaptic density protein-95, Drosophila disc large tumor suppressor, and zonula occludens-1. Date of download: 11/11/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.