Diagrammatic representation of the mechanism of action of testosterone on target cells. Testosterone (T) circulates in association with sex hormone–binding.

Slides:

Advertisements

Similar presentations

2 nd lecture: Communications among cells and tissues Classification of hormones in Several Ways: According to solubility According to chemical composition.

Advertisements

Synthesis of cortisol Stress Hypothalamus Pituitary Adrenal cortisol - ACTH + Adrenocorticotropic hormone - CRF CRF: corticotropic releasing hormone ACTH.

Chapter 24: Gonadal Steroids Katrien Venken, Steven Boonen, Roger Bouillon, and Dirk Vanderschueren.

Copyright © 2016 McGraw-Hill Education. All rights reserved.

18 F-deoxyglucose (18FDG) PET/CT fusion scan

(Modified from Hanley NA, Arlt W

Hormones of Testes - Testosterone Lecture NO: 2nd MBBS

Stage P1: Preadolescent; the vellus over the area is no further developed than that over the anterior abdominal wall (ie, no pubic hair). Stage P2: Sparse.

****Suppression of the serum TSH with levothyroxine has been shown to be of more benefit in patients with higher stages of disease. In older patients with.

Hypogonadism in aging men

(Adapted, with permission, from Fagin JA

A simplified schema for the regulation of serum phosphate by PTH, 1,25(OH)2D and fibroblast growth factor 23 (FGF23). FGF23 is produced predominantly by.

(The data are from Southard RN, et al

The bipotential gonad is differentiated into testes by the sex-determining region gene on the Y chromosome (Sry). This period of sex determination is followed.

Hands of a patient with pseudohypoparathyroidism

(Reproduced, with permission, from Findling JW, et al

A. Relationship between serum-free thyroxine by dialysis (FT4) ng/dL and log10 TSH in euthyroid, hyperthyroid, hypothyroid, and T4-suppressed euthyroid.

This patient has a total hip bone mineral density (BMD) of 0

(Reproduced, with permission, from Gougeon A

(Reproduced, with permission, from Findling JW

ARE ARE Prostate cancer cell Prostate cancer cell

This patient has a lumbar spine (L1-L4) bone mineral density (BMD) of g/cm2 (cross on the reference database graph) measured by dual-energy x-ray.

Structures of antiestrogens and aromatase inhibitors

Oral contraceptive pill hormonal components

Oral contraceptive pill hormonal components

Animal model for Graves disease

Serum medroxyprogesterone acetate (MPA) and estradiol levels following Lunelle injection. (Reproduced with permission from Rahimy MH, Ryan KK, Hopkins.

Comparative serum steroid (CSS) levels of norelgestromin (NGMN) and ethinyl estradiol (EE) following patch administration. (Reproduced with permission.

Biosynthesis and metabolism of testosterone

The stages of Reproductive Aging Workshop +10 staging system for reproductive aging in women. (Reproduced with permission from Harlow SD, Gass M, Hall.

(Reproduced, with permission, from Langman J, Sadler TW

Model of the interaction of T3 with the T3 receptor

Simplified (partial) mechanism for the cytosolic stress response

Leptin-melanocortin system of energy balance

Rodin, “The Kiss” (545 x 800). Accessed at

A. Magnified x-ray of index finger on fine-grain industrial film showing classic subperiosteal resorption in a patient with severe primary hyperparathyroidism.

One theory of the pathogenesis of Graves disease

A model of the interaction of a steroid, S (eg, cortisol), and its receptor, R, and the subsequent events in a target cell. The steroid is present in the.

Synthesis of calcitriol

Potential hormonal mediators of amenorrhea

Nutrient or ion regulation of hormone release

Screening for MEN1-associated neoplasia

Adjusting probabilities with new information and treatment thresholds

(Modified from Conlin PR, et al

Schema of the two zinc fingers, together with coordinated zinc ion, which make up the DNA-binding domain of the glucocorticoid receptor (amino acids are.

Model for the histological and genetic progression from normal cells (far left) through pancreatic intraepithelial neoplasia (PanIN) lesions (center),

Longitudinal effects of aging on date-adjusted testosterone (T) and free testosterone index (free T index). Linear segment plots for total T and free T.

Hypogonadism in aging men

An algorithm for women who have developed secondary sexual characteristics, have experienced menarche, and are presenting with amenorrhea or oligomenorrhea.

Renin-angiotensin-aldosterone and potassium-aldosterone feedback loops

This diagram illustrates adrenal, ovarian, and testicular steroidogenic pathways. Under the usual circumstances in humans, 17-OHP is a poor substrate for.

Responses of serum insulin to selective intra-arterial calcium stimulation in a patient with biochemical confirmation of inappropriate hyperinsulinism.

(Reproduced, with permission, from Fulop M, et al

Hypothalamic-pituitary-thyroid axis

John W. Bloom, MD Journal of Allergy and Clinical Immunology

HER2/HER3 heterodimers in prostate cancer

Figure 1 Intracellular regulation of the glucocorticoid receptor

Gonadal Steroid Action

therapy and to block androgen action

Testosterone Measurement in Patients with Prostate Cancer

Anjanette Acosta Physiology 3

Chapter 18a The Endocrine System

Take out a sheet of paper for a new page of notes

Development of Androgen Receptor Antagonists with Promising Activity in Castration- Resistant Prostate Cancer Howard C. Shen, Steven P. Balk Cancer Cell

William G. Nelson, Michael C. Haffner, Srinivasan Yegnasubramanian

Dynamic Remodeling of Transcription Complexes by Molecular Chaperones

Nat. Rev. Urol. doi: /nrurol

Factors that Mediate and Modulate Androgen Action

New Developments in the Medical Management of Prostate Cancer

Selective progesterone receptor modulators in reproductive medicine: pharmacology, clinical efficacy and safety Philippe Bouchard, M.D., Nathalie Chabbert-Buffet,

Presentation transcript:

Diagrammatic representation of the mechanism of action of testosterone on target cells. Testosterone (T) circulates in association with sex hormone–binding globulin (SHBG) but dissociates to enter the cells, where it is either 5α-reduced to dihydrotestosterone (DHT) or aromatized to estradiol (E2). Dihydrotestosterone binds to the androgen receptor (AR) in the cytoplasm and activates it with the release of heat shock proteins (HSP). The activated AR complex is then translocated to the nucleus, where it binds as a dimer to specific hormone response elements of the DNA and, along with coactivators (eg, ARA), initiates transcription, leading to protein synthesis with consequent androgenic effects. (Redrawn and modified from Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer. 2001;1:34.) Source: Chapter 14. Disorders of Sex Determination and Differentiation, Greenspan’s Basic & Clinical Endocrinology, 9e Citation: Gardner DG, Shoback D. Greenspan’s Basic & Clinical Endocrinology, 9e; 2011 Available at: https://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/gard9/gard9_c014f011.gif&sec=39748491&BookID=380&ChapterSecID=39744054&imagename= Accessed: November 11, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved