Stroke John C. Stevenson Martin Birkhäuser Alfred O. Mueck.

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Presentation transcript:

Stroke John C. Stevenson Martin Birkhäuser Alfred O. Mueck

Stroke 1. Risk factors, absolute risks 2. MHT – WHI, RCTs 3. MHT – Observational Studies 4. Tibolone, SERMs 5. Experimental Research 6. Stroke prevention, Guidelines, Consensus Statement Structure of this presentation!

Stroke 1. Risk factors, absolute risks 2. MHT – WHI, RCTs 3. MHT – Observational Studies 4. Tibolone, SERMs 5. Experimental Research 6. Stroke prevention, Guidelines, Consensus Statement

Increased stroke risk Age History/family history Prior stroke, TIA, MI Atrial fibrillation Gender Incidence greater in males Mortality greater in females Hypertension Smoking Diabetes mellitus Arterial disease Carotid, peripheral, coronary Lifestyle diet, exercise Besides age are hypertension and smoking the morst important risk factors.

Stroke Ischemic (thrombotic/embolic) 86% Hemorrhagic Intracerebral 10% Subarachnoid 4% The diagnosis to differ between ischemic stroke and hemorraghic stroke must be made as soon as possible by computertomography. MHT is a risk factor for ischemic stroke.

Female stroke prevalence USA females, 2004 www.americanheart.org