From: Integrated Comparison of GWAS, Transcriptome, and Proteomics Studies Highlights Similarities in the Biological Basis of Animal and Human Myopia Invest.

Slides:

Advertisements

Similar presentations

From: Iontophoresis Transcorneal Delivery Technique for Transepithelial Corneal Collagen Crosslinking With Riboflavin in a Rabbit Model Invest. Ophthalmol.

Advertisements

Invest. Ophthalmol. Vis. Sci ;48(10): doi: /iovs Figure Legend:

From: Enhanced Motion Aftereffects in Migraine Are Related to Contrast Sensitivity: Implications for Models of Differences in Precortical/Cortical Function.

From: Advantages of Using Mitochondrial 16S rDNA Sequences to Classify Clinical Isolates of Acanthamoeba Invest. Ophthalmol. Vis. Sci ;44(3):

Invest. Ophthalmol. Vis. Sci ;49(7): doi: /iovs Figure Legend:

From: Increased Choroidal Neovascularization following Laser Induction in Mice Lacking Lysyl Oxidase-like 1 Invest. Ophthalmol. Vis. Sci ;49(6):

Invest. Ophthalmol. Vis. Sci ;57(1): doi: /iovs Figure Legend:

From: Postnatal Gene Expression in the Normal Mouse Cornea by SAGE

From: Postnatal Gene Expression in the Normal Mouse Cornea by SAGE

From: Glycogene Expression in Conjunctiva of Patients with Dry Eye: Downregulation of Notch Signaling Invest. Ophthalmol. Vis. Sci ;50(6):

Invest. Ophthalmol. Vis. Sci ;49(1): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;52(1): doi: /iovs Figure Legend:

From: The Controlled-Environment Chamber: A New Mouse Model of Dry Eye

From: Comparative Transcriptome and Network Biology Analyses Demonstrate Antiproliferative and Hyperapoptotic Phenotypes in Human Keratoconus Corneas Invest.

From: Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye Invest. Ophthalmol.

From: Stereotactic Radiosurgery for AMD: A Monte Carlo–Based Assessment of Patient-Specific Tissue Doses Invest. Ophthalmol. Vis. Sci ;52(5):

From: Which Members of a Community Need Antibiotics to Control Trachoma? Conjunctival Chlamydia trachomatis Infection Load in Gambian Villages Invest.

From: What You See Is What You Step: The Horizontal–Vertical Illusion Increases Toe Clearance in Older Adults During Stair Ascent Invest. Ophthalmol. Vis.

Invest. Ophthalmol. Vis. Sci ;43(6): Figure Legend:

Invest. Ophthalmol. Vis. Sci ;45(6): doi: /iovs Figure Legend:

Figure Legend: From: Engineering a Light-Attenuating Artificial Iris

Invest. Ophthalmol. Vis. Sci ;52(5): doi: /iovs Figure Legend:

From: Stereo Photo Measured ONH Shape Predicts Development of POAG in Subjects With Ocular Hypertension Invest. Ophthalmol. Vis. Sci ;56(8):

From: Long-Term, Targeted Genetic Modification of the Aqueous Humor Outflow Tract Coupled with Noninvasive Imaging of Gene Expression In Vivo Invest. Ophthalmol.

Invest. Ophthalmol. Vis. Sci ;57(13): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;48(10): doi: /iovs Figure Legend:

From: Integrated Comparison of GWAS, Transcriptome, and Proteomics Studies Highlights Similarities in the Biological Basis of Animal and Human Myopia Invest.

Invest. Ophthalmol. Vis. Sci ;58(1): doi: /iovs Figure Legend:

From: Comparison of High-Resolution Melting Analysis with Denaturing High-Performance Liquid Chromatography for Mutation Scanning in the ABCA4 Gene Invest.

From: Systemic Treatment With Glutathione PEGylated Liposomal Methylprednisolone (2B3-201) Improves Therapeutic Efficacy in a Model of Ocular Inflammation.

From: Uvemaster: A Mobile App-Based Decision Support System for the Differential Diagnosis of Uveitis Invest. Ophthalmol. Vis. Sci ;58(10):

From: Phenotypes and Biomarkers of Diabetic Retinopathy

From: Evaluation of the X-Linked High-Grade Myopia Locus (MYP1) with Cone Dysfunction and Color Vision Deficiencies Invest. Ophthalmol. Vis. Sci ;50(4):

From: Refractive Error, Ocular Biometry, and Lens Opalescence in an Adult Population: The Los Angeles Latino Eye Study Invest. Ophthalmol. Vis. Sci ;46(12):

From: Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats Invest. Ophthalmol. Vis. Sci..

Invest. Ophthalmol. Vis. Sci ;57(4): doi: /iovs Figure Legend:

From: Dependable and Efficient Clinical Utility of Target Capture-Based Deep Sequencing in Molecular Diagnosis of Retinitis Pigmentosa Invest. Ophthalmol.

From: Effects of Sildenafil and Tadalafil on Intraocular Pressure in Sheep: Implications for Aqueous Humor Dynamics Invest. Ophthalmol. Vis. Sci ;51(6):

Figure Legend: From: High-Fat Diet–Induced Retinal Dysfunction

From: Macular Choroidal Thickness and Volume in Normal Subjects Measured by Swept-Source Optical Coherence Tomography Invest. Ophthalmol. Vis. Sci ;52(8):

Invest. Ophthalmol. Vis. Sci ;58(4): doi: /iovs Figure Legend:

From: Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy Invest. Ophthalmol. Vis. Sci ;58(1):

From: Evaluation of Corneal Displacement Using High-Speed Photography at the Early and Late Phases of Noncontact Tonometry Invest. Ophthalmol. Vis. Sci..

From: One-Year Outcome of 49-Channel Suprachoroidal–Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa Invest. Ophthalmol.

From: Genetic Polymorphisms in the Promoter of the Interferon Gamma Receptor 1 Gene Are Associated with Atopic Cataracts Invest. Ophthalmol. Vis. Sci..

Invest. Ophthalmol. Vis. Sci ;51(9): doi: /iovs Figure Legend:

From: Canonical/β-Catenin Wnt Pathway Activation Improves Retinal Pigmented Epithelium Derivation From Human Embryonic Stem Cells Invest. Ophthalmol. Vis.

From: Inhibition of miR-205 Impairs the Wound-Healing Process in Human Corneal Epithelial Cells by Targeting KIR4.1 (KCNJ10) Invest. Ophthalmol. Vis. Sci..

From: An Experimental Protocol of the Model to Quantify Traction Applied to the Retina by Vitreous Cutters Invest. Ophthalmol. Vis. Sci ;51(8):

From: Experimental Glaucoma and Optic Nerve Transection Induce Simultaneous Upregulation of Proapoptotic and Prosurvival Genes Invest. Ophthalmol. Vis.

From: Analysis of Rare Variants in the Complement Component 2 (C2) and Factor B (BF) Genes Refine Association for Age-Related Macular Degeneration (AMD)

From: Adenovirus Type 37 Keratitis in the C57BL/6J Mouse

Invest. Ophthalmol. Vis. Sci ;54(5): doi: /iovs Figure Legend:

From: Alterations in Protein Expression in Tree Shrew Sclera during Development of Lens-Induced Myopia and Recovery Invest. Ophthalmol. Vis. Sci ;53(1):

From: Mesenchymal Stem Cells Ameliorate Experimental Autoimmune Uveoretinitis by Comprehensive Modulation of Systemic Autoimmunity Invest. Ophthalmol.

Invest. Ophthalmol. Vis. Sci ;53(1): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;46(4): doi: /iovs Figure Legend:

From: Threshold and Variability Properties of Matrix Frequency-Doubling Technology and Standard Automated Perimetry in Glaucoma Invest. Ophthalmol. Vis.

From: Expression of PRPF31 mRNA in Patients with Autosomal Dominant Retinitis Pigmentosa: A Molecular Clue for Incomplete Penetrance? Invest. Ophthalmol.

From: An Investigative Peptide–Acyclovir Combination to Control Herpes Simplex Virus Type 1 Ocular Infection Invest. Ophthalmol. Vis. Sci ;54(9):

Invest. Ophthalmol. Vis. Sci ;52(9): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;57(2): doi: /iovs Figure Legend:

From: Disease Expression in Autosomal Recessive Retinal Dystrophy Associated With Mutations in the DRAM2 Gene Invest. Ophthalmol. Vis. Sci ;56(13):

From: Higher Contrast Requirement for Letter Recognition and Macular RGC+ Layer Thinning in Glaucoma Patients and Older Adults Invest. Ophthalmol. Vis.

Invest. Ophthalmol. Vis. Sci ;58(7): doi: /iovs Figure Legend:

From: Cold-Sensitive Corneal Afferents Respond to a Variety of Ocular Stimuli Central to Tear Production: Implications for Dry Eye Disease Invest. Ophthalmol.

From: Scanning Laser Polarimetry with Variable Corneal Compensation: Identification and Correction for Corneal Birefringence in Eyes with Macular Disease.

From: Experimental Glaucoma and Optic Nerve Transection Induce Simultaneous Upregulation of Proapoptotic and Prosurvival Genes Invest. Ophthalmol. Vis.

From: Adenovirus Type 37 Keratitis in the C57BL/6J Mouse

Invest. Ophthalmol. Vis. Sci ;53(12): doi: /iovs Figure Legend:

Presentation transcript:

From: Integrated Comparison of GWAS, Transcriptome, and Proteomics Studies Highlights Similarities in the Biological Basis of Animal and Human Myopia Invest. Ophthalmol. Vis. Sci.. 2017;58(1):660-669. doi:10.1167/iovs.16-20618 Figure Legend: Heatmaps showing overlap of the genes within 1 Mb, 500 kb, and 250 kb of GWAS loci with the genes differentially expressed in animal transcriptome studies of (A) myopia induction and (B) growth slowing (GS). Heatmaps showing overlap of the genes within 1 Mb, 500 kb, and 250 kb of GWAS loci with the genes differentially expressed in animal proteomics studies of (C) myopia induction and (D) GS. Heatmaps showing overlap of the genes differentially expressed in animal transcriptome and proteomics studies of (E) myopia induction and (F) GS. The color of each heatmap square represents the odds ratio (larger odds ratios indicate a stronger association between lists), and the number of overlapping genes and significant Benjamini-Hochberg–adjusted P values (in parentheses where applicable) are superimposed on the grids. Arrows indicate the fold-change direction of differential expression in transcriptome and proteomics studies, and the number of genes implicated in each list is shown in parentheses after the list name. Note that the length of each list is a key factor determining overlap significance. Date of download: 11/11/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.