Premature immune senescence during HIV-1 vertical infection relates with response to influenza vaccination Alberto Cagigi, PhD, Stefano Rinaldi, MSc,

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Premature immune senescence during HIV-1 vertical infection relates with response to influenza vaccination Alberto Cagigi, PhD, Stefano Rinaldi, MSc, Angela Di Martino, PhD, Emma Concetta Manno, MD, Paola Zangari, MD, Angela Aquilani, MD, Nicola Cotugno, MD, Luciana Nicolosi, MD, Alberto Villani, MD, Stefania Bernardi, MD, Isabella Donatelli, PhD, Savita Pahwa, MD, Paolo Rossi, MD, Paolo Palma, MD Journal of Allergy and Clinical Immunology Volume 133, Issue 2, Pages 592-594.e1 (February 2014) DOI: 10.1016/j.jaci.2013.10.003 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Scatter plot analyses (Mann-Whitney U test) on the percentage of MA (A) and DN (B) B cells in HIV-1-positive patients and HC. Horizontal lines represent the mean ± SD. C, Spearman correlation between the frequencies of MA or DN B cells and the vaccination outcome in terms of fold increase postvaccination (from left to right for H1N1, H3N2, and B influenza strains) and the frequencies of MA or DN B cells in all subjects (both HIV-1-positive and HC). Open circles indicate data for the MA while closed circles indicate data for the DN B cells. The frequencies of both MA and DN were measured before vaccination (T0). Journal of Allergy and Clinical Immunology 2014 133, 592-594.e1DOI: (10.1016/j.jaci.2013.10.003) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Spearman correlation between the frequencies of MA or DN B cells and terminal effector CD4+ T cells (A) and between the levels of IL-21R expression in B cells (B) measured at T0 and the plasma levels of BAFF at T1 in all subjects (both HIV-1-positive and HC) (C). Open circles indicate data for the MA and closed circles for the DN B cells. The frequencies of both MA and DN were measured before vaccination (T0). Journal of Allergy and Clinical Immunology 2014 133, 592-594.e1DOI: (10.1016/j.jaci.2013.10.003) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions