HLA Association with Hematopoietic Stem Cell Transplantation Outcome: The Number of Mismatches at HLA-A, -B, -C, -DRB1, or -DQB1 Is Strongly Associated.

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Presentation transcript:

HLA Association with Hematopoietic Stem Cell Transplantation Outcome: The Number of Mismatches at HLA-A, -B, -C, -DRB1, or -DQB1 Is Strongly Associated with Overall Survival Pascale Loiseau, Marc Busson, Marie-Lorraine Balere, Anne Dormoy, Jean-Denis Bignon, Katia Gagne, Lucette Gebuhrer, Valérie Dubois, Isabelle Jollet, Monique Bois, Pascale Perrier, Dominique Masson, Agnès Moine, Léna Absi, Denis Reviron, Virginia Lepage, Ryad Tamouza, Antoine Toubert, Evelyne Marry, Zina Chir, Jean-Pierre Jouet, Didier Blaise, Dominique Charron, Colette Raffoux Biology of Blood and Marrow Transplantation Volume 13, Issue 8, Pages 965-974 (August 2007) DOI: 10.1016/j.bbmt.2007.04.010 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Effect of number of HLA-A, -B, -C, -DRB1, or -DQB1 mismatches on grade III-IV aGVHD. Biology of Blood and Marrow Transplantation 2007 13, 965-974DOI: (10.1016/j.bbmt.2007.04.010) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Effect of number of HLA-A, -B, -C, -DRB1, or -DQB1 mismatches on overall survival. Biology of Blood and Marrow Transplantation 2007 13, 965-974DOI: (10.1016/j.bbmt.2007.04.010) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Effect of HLA-B mismatches on overall survival on 208 grafts identical for HLA-A, -C, -DRB1, or -DQB1. Biology of Blood and Marrow Transplantation 2007 13, 965-974DOI: (10.1016/j.bbmt.2007.04.010) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Effect of of HLA-C mismatches on overall survival on 254 grafts identical for HLA-A, -B, -DRB1, or -DQB1. Biology of Blood and Marrow Transplantation 2007 13, 965-974DOI: (10.1016/j.bbmt.2007.04.010) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions