New Tracers for Prostate Cancer Imaging Stefano Fanti

Imaging of Prostate Cancer

OLD TRACERS NEW TRACERS CURRENT TRACERS NEW TRACERS Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

Is Choline PET outdated ?

RECURRENCE Patient treated with radical prostatectomy for PCa 4+4, T3bN1(2/24) MxR0, presentation PSA=12.1 ng/mL in April 2009. Biochemical relapse occurred 11 months after surgery, with rising PSA levels (PSA 2.1 ng/mL in 10/2010). Patient was addressed to ADT with continuous scheme (bicalutamide + LH-RH inhibitor), experiencing PSA response (PSA values <0.2 ng/mL). In October 2012 biochemical relapse occurred with rising PSA levels during ADT . Patient was subsequently referred to 11C- choline PET/CT with PSA value of 0.88 ng/mL, that showed a diffuse bone metastatic invasion together with lymph-node relapse. The patient was addressed to chemotherapy (Docetaxel) according to the diffuse metastatic spread revealed by 11C-choline PET/CT.

Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

RECURRENCE Prostatectomy PSA 1.3 ng/Ml DT 3 months BS neg

RECURRENCE Prostatectomy PSA 0.9 ng/mL BS neg

11C-CHOLINE

CHOLINE PET/CT Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

CURRENT TRACERS Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

PSMA TRACERS

68Ga-PSMA 18F-CHOLINE

Images courtesy of prof Haberkorn - Heidelberg 68Ga-PSMA 18F-CHOLINE Images courtesy of prof Haberkorn - Heidelberg

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68Ga-PSMA

Only 1 exam

PSMA PET/CT Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

Impact

Impact

NEW TRACERS

Fluciclovine

Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

Detection Rate BCR with > 1.0 PSA < 2.0

Detection Rate BCR with PSA < 1.0

Gleason 5+4 (01/30/2007) presenting with a T2b nodule and PSA of 5.4 High grade prostate cancer involving 6/12 cores 21 months of androgen blockade Intensity modulated pelvic XRT in 2007 PSA nadir in February 2011 was 0.11 Biochemical recurrence in 2011 MIP PET 68Ga RM2 MIP PET 68Ga PSMA 68GA-BOM Images courtesy of prof Iagaru - Stanford

NEW TRACERS PET/CT Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis.

68GA-BOM 18F-FACBC 68GA-PSMA 11C-CHOLINE 18F-PSMA

Many years ago, we published this work in JNM about the accuracy of PET/CT for the intra prostatic detection of cancer foci. We studied 31 patients and compared PET results with histopathology on a sextant basis. THANK YOU