The dose–response of salvage radiotherapy following radical prostatectomy: A systematic review and meta-analysis Christopher R. King Radiotherapy and.

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The dose–response of salvage radiotherapy following radical prostatectomy: A systematic review and meta-analysis Christopher R. King Radiotherapy and Oncology Volume 121, Issue 2, Pages 199-203 (November 2016) DOI: 10.1016/j.radonc.2016.10.026 Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 PSA relapse-free survival vs. SRT dose for all eligible salvage RT studies. In this bubble plot the number of patients in each series is reflected by the size of each circle. The data are well fit by a sigmoidal dose–response curve (dashed curve, Spearman’s rho=0.444, p=0.0001). The fitted TCD50=65.8Gy, and there’s a 2.0% [95% CI 1.1–3.2] improvement in RFS achieved for each additional Gy. Dose is assumed delivered at conventional fractionation (1.8–2Gy per daily fraction). Radiotherapy and Oncology 2016 121, 199-203DOI: (10.1016/j.radonc.2016.10.026) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 PSA relapse-free survival vs. RT dose for definitive RT studies. A sigmoidal dose–response curve (solid curve) is fit to the data, yielding a TCD50=65.9Gy and a 2.6% improvement in RFS achieved for each additional Gy. The dose–response curve for salvage RT (dashed curve) from Fig. 1 is superimposed for comparison. Dose is assumed delivered at conventional fractionation (1.8–2Gy per daily fraction). Radiotherapy and Oncology 2016 121, 199-203DOI: (10.1016/j.radonc.2016.10.026) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions