A meta-analysis on the effect of dietary application of exogenous fibrolytic enzymes on the performance of dairy cows Kathy G. Arriola, Andre S. Oliveira,

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Presentation transcript:

A meta-analysis on the effect of dietary application of exogenous fibrolytic enzymes on the performance of dairy cows Kathy G. Arriola, Andre S. Oliveira, Zhengxin X. Ma, Ian J. Lean, Mihai C. Giurcanu, Adegbola T. Adesogan Journal of Dairy Science Volume 100, Issue 6, Pages 4513-4527 (June 2017) DOI: 10.3168/jds.2016-12103 Copyright © 2017 American Dairy Science Association Terms and Conditions

Figure 1 Forest plot of random effects of standardized mean difference (SMD) between control and treatment means for milk yield classified by enzyme type. A-EPE, C-X, C-FAE, FAE, En-X, and X represent studies involving the following enzyme types: amylase-proteolytic enzymes, cellulase-xylanase, cellulase-ferulic acid esterase, ferulic acid esterase, endoglucanase-xylanase, and xylanase, respectively. The solid diamonds represent individual studies and their weighting by the inverse of their respective variances. The horizontal lines represent the 95% confidence interval for the study. The open diamond represents the overall SMD and its width represents the associated 95% confidence interval. The solid line is the line depicting no treatment effect. The dotted line indicates the average response to exogenous fibrolytic enzyme treatment across studies as well as the heterogeneity of the studies by not passing through all the solid diamonds. Journal of Dairy Science 2017 100, 4513-4527DOI: (10.3168/jds.2016-12103) Copyright © 2017 American Dairy Science Association Terms and Conditions

Figure 2 Forest plot random effects standardized mean difference (SMD) between control and treatment means for DMI. The solid diamonds represent individual studies and their weighting by the inverse of their respective variances. The horizontal lines represent the 95% confidence interval for the study. The open diamond represents the overall SMD and its width represents the associated 95% confidence interval. The solid line is the line depicting no treatment effect. The dotted line indicates the average response to exogenous fibrolytic enzyme treatment across studies as well as the heterogeneity of the studies by not passing through all the solid diamonds. Journal of Dairy Science 2017 100, 4513-4527DOI: (10.3168/jds.2016-12103) Copyright © 2017 American Dairy Science Association Terms and Conditions

Figure 3 Forest plot of random effects standardized mean difference (SMD) between control and treatment means for milk protein content as affected by enzyme application method (i.e., 1 = to the concentrate, 2 = to the forage, 3 = to the TMR). The solid diamonds represent individual studies and their weighting by the inverse of their respective variances. The horizontal lines represent the 95% confidence interval for the study. The open diamond represents the overall SMD and its width represents the associated 95% confidence interval. The solid line is the line depicting no treatment effect. The dotted line indicates the average response to exogenous fibrolytic enzyme treatment across studies as well as the heterogeneity of the studies by not passing through all the solid diamonds. Journal of Dairy Science 2017 100, 4513-4527DOI: (10.3168/jds.2016-12103) Copyright © 2017 American Dairy Science Association Terms and Conditions

Figure 4 Contour-line enhanced funnel plot of the standardized mean difference between treatment and control groups in all studies in the meta-analysis of effect of exogenous fibrolytic enzyme treatment on milk yield. This funnel plot represents a slight bias toward publishing favorable studies. Journal of Dairy Science 2017 100, 4513-4527DOI: (10.3168/jds.2016-12103) Copyright © 2017 American Dairy Science Association Terms and Conditions

Figure 5 Contour-line enhanced funnel plot of the standardized mean difference between treatment and control groups in all studies in the meta-analysis of effect of exogenous fibrolytic enzyme treatment on DMI. This funnel plot represents a slight bias toward publishing favorable studies. Journal of Dairy Science 2017 100, 4513-4527DOI: (10.3168/jds.2016-12103) Copyright © 2017 American Dairy Science Association Terms and Conditions

Figure A1 Forest plot of the effect of enzyme application on milk yield. The solid diamonds represent individual studies and their weighting by the inverse of their respective variances. The horizontal lines represent the 95% confidence interval for the study. The open diamond represents the 95% confidence interval for the overall estimate. The solid line represents a mean difference of zero or no effect. The dotted line indicates the mean response as well as the heterogeneity of the studies by not passing through all the solid diamonds. RMD = raw mean difference; WMD = weighted mean difference. Journal of Dairy Science 2017 100, 4513-4527DOI: (10.3168/jds.2016-12103) Copyright © 2017 American Dairy Science Association Terms and Conditions

Figure A2 Forest plot of the effect of enzyme application on DMI. The solid diamonds represent individual studies and their weighting by the inverse of their respective variances. The horizontal lines represent the 95% confidence interval for the study. The open diamond represents 95% confidence interval for the overall estimate. The solid line represents a mean difference of zero or no effect. The dotted line indicates the mean response as well as the heterogeneity of the studies by not passing through all the solid diamonds. RMD = raw mean difference. Journal of Dairy Science 2017 100, 4513-4527DOI: (10.3168/jds.2016-12103) Copyright © 2017 American Dairy Science Association Terms and Conditions

Figure A3 Contour-line enhanced funnel plot of the raw mean difference between treatment and control groups in all studies in the meta-analysis of effect of exogenous fibrolytic enzyme treatment on milk yield. This funnel plot depicts a slight bias toward publishing favorable studies. Journal of Dairy Science 2017 100, 4513-4527DOI: (10.3168/jds.2016-12103) Copyright © 2017 American Dairy Science Association Terms and Conditions

Figure A4 Contour-line enhanced funnel plot of the raw mean difference between treatment and control groups in all studies in the meta-analysis of effect of exogenous fibrolytic enzyme treatment on DMI. This funnel plot depicts a slight bias toward publishing favorable studies. Journal of Dairy Science 2017 100, 4513-4527DOI: (10.3168/jds.2016-12103) Copyright © 2017 American Dairy Science Association Terms and Conditions