Differential effects of vascular growth factors on arterial and venous angiogenesis John Blebea, MD, a, Jonathan-Hien Vu, MD, a, Shahin Assadnia, MD,

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Presentation transcript:

Differential effects of vascular growth factors on arterial and venous angiogenesis John Blebea, MD, a, Jonathan-Hien Vu, MD, a, Shahin Assadnia, MD, a, Patricia J. McLaughlin, DEdb, Robert G. Atnip, MD, a, Ian S. Zagon, PhDb Journal of Vascular Surgery Volume 35, Issue 3, Pages 532-538 (March 2002) DOI: 10.1067/mva.2002.120042 Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 Digitized computer images of CAMs. White circles represent location of applied disks. Artery is oriented vertically with blood flowing antegrade from bottom to top of each illustration; veins have blood flowing in opposite direction. Arterial branches are indicated by arrow whereas venous branches are shown by arrowhead.A, Control specimen with venous branches intercalating between arterioles. B, Specimen exposed to VEGF shows increased vascularity. C, Treatment with opioid growth factor decreased number of arteries and veins in region of applied disk. D, Application of retinoic acid diminished growth of arteries and veins. All photographs were performed at same magnification (bar = 2 mm), with unselected variability in vessel size. Journal of Vascular Surgery 2002 35, 532-538DOI: (10.1067/mva.2002.120042) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Total number of blood vessels in region around applied disks. Number of blood vessels was increased after exposure to VEGF (1.0 μg) or naltrexone (NTX, 5.0 μg) but was decreased in preparations treated with OGF (1.0 μg, 5.0 μg) and retinoic acid (RA, 1.0 μg) compared with controls. Significantly different from controls at *P <.05; §P <.005; and #P <.0001. Journal of Vascular Surgery 2002 35, 532-538DOI: (10.1067/mva.2002.120042) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 3 Total blood vessel length in region around applied disks in CAMs exposed to VEGF (1.0 μg) or naltrexone (NTX, 5.0 μg) was significantly increased whereas in preparations treated with OGF (1.0 μg, 5.0 μg) or retinoic acid (RA, 1.0 μg), blood vessel length decreased. Significantly different from controls at *P <.05; §P <.005; and #P <.0001. Journal of Vascular Surgery 2002 35, 532-538DOI: (10.1067/mva.2002.120042) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 4 Mean blood vessel length in 100 mm2 region around disks. VEGF (1.0 μg) and naltrexone (NTX, 5.0 μg) groups demonstrated significant decrease compared with control group, whereas OGF (1.0 μg, 5.0 μg) and retinoic acid (RA, 1.0 μg) increased mean blood vessel length. Significantly different from controls at *P <.05 and #P <.0001. Differential effects of angiogenic mediators on CAM preparations Journal of Vascular Surgery 2002 35, 532-538DOI: (10.1067/mva.2002.120042) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions