Figure 1. Number of CCDS IDs and genes represented in the human (A) and mouse (B) CCDS releases. The X-axis indicates the year in which a CCDS dataset.

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Figure 1. Number of CCDS IDs and genes represented in the human (A) and mouse (B) CCDS releases. The X-axis indicates the year in which a CCDS dataset was made public. Details about CCDS releases are available on the CCDS Releases and Statistics web page (https://www.ncbi.nlm.nih.gov/CCDS/CcdsBrowse.cgi?REQUEST=SHOW_STATISTICS). From: Consensus coding sequence (CCDS) database: a standardized set of human and mouse protein-coding regions supported by expert curation Nucleic Acids Res. Published online November 06, 2017. doi:10.1093/nar/gkx1031 Nucleic Acids Res | Published by Oxford University Press on behalf of Nucleic Acids Research 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Figure 2. Fraction of all genes in a CCDS release that are represented by at least two current CCDS IDs. From: Consensus coding sequence (CCDS) database: a standardized set of human and mouse protein-coding regions supported by expert curation Nucleic Acids Res. Published online November 06, 2017. doi:10.1093/nar/gkx1031 Nucleic Acids Res | Published by Oxford University Press on behalf of Nucleic Acids Research 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Figure 3. Changes in the human (A) and mouse (B) datasets with every new CCDS release. ‘New’ = new CCDS IDs added; ‘dropped’ = CCDS ID present in the previous release but withdrawn in the subsequent release; ‘updated’ = CCDS IDs that have an incremented accession version compared to the previous release, indicating a sequence update in the coding region. From: Consensus coding sequence (CCDS) database: a standardized set of human and mouse protein-coding regions supported by expert curation Nucleic Acids Res. Published online November 06, 2017. doi:10.1093/nar/gkx1031 Nucleic Acids Res | Published by Oxford University Press on behalf of Nucleic Acids Research 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Figure 4. A view of the graphical display accessed from the report page of CCDS3542.1 (https://www.ncbi.nlm.nih.gov/CCDS/CcdsBrowse.cgi?REQUEST=ALLFIELDS&DATA=CCDS3542&ORGANISM=0&BUILDS=CURRENTBUILDS) using the purple ‘S’ icon. (A) Transcripts and proteins from NCBI Annotation Release 108. (B) Transcripts and proteins from Ensembl Release 85. The green bar indicates the gene; transcripts are shown in purple and proteins are shown in red color. Positioning the cursor over any of these objects (gene, transcript or protein) opens a tool tip which includes additional information and links. Proteins in the NCBI annotation display that are in the CCDS set include a link to the CCDS ID in the tool tip. The gray box to the right (indicated by vertical arrow) is the tool tip corresponding to the protein accession NP_002514.1. Differences between any two objects can also be revealed as vertical lines (indicated by horizontal arrows) when the objects (NM_002523.2 and ENST00000265634 in the figure) are selected using the ‘Control’ or ‘Command’ button on the keyboard. From: Consensus coding sequence (CCDS) database: a standardized set of human and mouse protein-coding regions supported by expert curation Nucleic Acids Res. Published online November 06, 2017. doi:10.1093/nar/gkx1031 Nucleic Acids Res | Published by Oxford University Press on behalf of Nucleic Acids Research 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Figure 5. Distribution of human and mouse CCDS IDs by their ‘Review status’ in the current human (Release 20) and mouse (Release 21) CCDS releases at the time of data freeze. Details of the review status categories and sub-categories are provided in Table 1. Reviewed 1 = CCDS IDs reviewed ‘by RefSeq and HAVANA’, Reviewed 2 = CCDS IDs reviewed ‘by CCDS collaboration’, Reviewed 3 = CCDS IDs reviewed ‘by RefSeq, HAVANA and CCDS collaboration’. From: Consensus coding sequence (CCDS) database: a standardized set of human and mouse protein-coding regions supported by expert curation Nucleic Acids Res. Published online November 06, 2017. doi:10.1093/nar/gkx1031 Nucleic Acids Res | Published by Oxford University Press on behalf of Nucleic Acids Research 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.