Efficacy and tolerability of systemic methylprednisolone in children and adolescents with chronic rhinosinusitis: A double-blind, placebo-controlled randomized.

Slides:



Advertisements
Similar presentations
Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Advertisements

D-dimer: A biomarker for antihistamine-resistant chronic urticaria
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
What drives prescription patterns in pediatric asthma management?
Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: A randomized, double-blind, placebo-controlled trial  Kaarina.
Treatment of nasal polyposis and chronic rhinosinusitis with fluticasone propionate nasal drops reduces need for sinus surgery  Albertien A.C. Aukema,
Reduced exhaled nitric oxide values in children with asthma after inpatient rehabilitation at high altitude  Johannes Huss-Marp, MD, Ursula Krämer, PhD,
Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo  Eli O. Meltzer, MD, Claus Bachert,
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Fluticasone furoate nasal spray: A single treatment option for the symptoms of seasonal allergic rhinitis  Harold B. Kaiser, MD, Robert M. Naclerio, MD,
Chronic Rhinosinusitis
Chronic rhinosinusitis: Potential new use for topical sulfasalazine
Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blind pilot trial  Jens U. Ponikau, MD, David.
Dennis K. Ledford, MD, Sally Wenzel, MD 
Is 9 more than 2 also in allergic airway inflammation?
Probiotics during the first 7 years of life: A cumulative risk reduction of eczema in a randomized, placebo-controlled trial  Marko Kalliomäki, MD, PhD,
Desensitization to Chemotherapeutic Agents
Preventive effect of nasal filters on allergic rhinitis: A randomized, double-blind, placebo- controlled crossover park study  Peter Kenney, BSc, Ole Hilberg,
Bruce M. Prenner, MD, Bobby Q. Lanier, MD, David I
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
An Infant with Atopic Dermatitis and Itching After Ingestion of Milk
Double-Blind, Placebo-Controlled, Randomized Trial of Octreotide in Malignant Bowel Obstruction  David C. Currow, FRACP, Stephen Quinn, PhD, Meera Agar,
Oral phenylephrine: An ineffective replacement for pseudoephedrine?
Double-blind placebo-controlled randomized clinical trial of verapamil for chronic rhinosinusitis with nasal polyps  Marcel M. Miyake, MD, Angela Nocera,
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Reply Journal of Allergy and Clinical Immunology
A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine–refractory chronic idiopathic urticaria 
Peter M. Wolfgram, MD, David B. Allen, MD 
Asthma treatment and asthma prevention: A tale of 2 parallel pathways
Successful management of mite-allergic asthma with modified extracts of Dermatophagoides pteronyssinus and Dermatophagoides farinae in a double-blind,
Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA 
Reply Journal of Allergy and Clinical Immunology
Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation  Leif Bjermer, MD  Journal of Allergy.
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management  Scott H. Sicherer, MD, Hugh A. Sampson, MD  Journal.
Biosimilars and drug development in allergic and immunologic diseases
Efficacy of house dust mite sublingual immunotherapy tablet in North American adolescents and adults in a randomized, placebo-controlled trial  Hendrik.
A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity  Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,
Claus Bachert, MD, PhD, Cezmi A. Akdis, MD 
What is an “eosinophilic phenotype” of asthma?
Cephalosporin Side Chain Cross-reactivity
Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: A randomized, double-blind clinical trial  Michael Weschta, MD, Dagmar Rimek,
Treating acute rhinosinusitis: Comparing efficacy and safety of mometasone furoate nasal spray, amoxicillin, and placebo  Eli O. Meltzer, MD, Claus Bachert,
H. William Kelly, PharmD  Journal of Allergy and Clinical Immunology 
Autophagy: Nobel Prize 2016 and allergy and asthma research
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment
Advances in the approach to the patient with food allergy
Diagnosis and management of early asthma in preschool-aged children
A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children  Felicia A. Rabito, PhD, MPH, John C. Carlson,
Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: A randomized, double-blind, placebo-controlled study  Giovanni B. Pajno,
One step forward, 2 steps back: The enigma of preschool wheeze
Biology of nasal polyposis
Sonja A. Grundmann, MD, Pia B. Hemfort, MD, Thomas A
Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A
Measles and immunomodulation
Short course of systemic corticosteroids in sinonasal polyposis: A double-blind, randomized, placebo-controlled trial with evaluation of outcome measures 
Managing asthma exacerbations in the emergency department: Summary of the National Asthma Education and Prevention Program Expert Panel Report 3 guidelines.
Macrolide antibiotics and asthma treatment
Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge  Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.
Asthma: The past, future, environment, and costs
Charcot-Leyden crystal concentration in nasal secretions predicts clinical response to glucocorticoids in patients with chronic rhinosinusitis with nasal.
Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization.
Environmental factors and eosinophilic esophagitis
Advances in pediatric asthma in 2007
Double-blind, placebo-controlled study with a modified therapeutic vaccine of Salsola kali (Russian thistle) administered through use of a cluster schedule 
Safety and efficacy of repeated monthly carboplatin desensitization
Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma  Philippe Gevaert, MD, PhD, Lien Calus, MD, Thibaut Van Zele,
Efficacy and tolerability of systemic methylprednisolone in children and adolescents with chronic rhinosinusitis: A double-blind, placebo-controlled randomized.
Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease  Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,
Natural history of cow’s milk allergy
Primary prevention of asthma and allergy
Presentation transcript:

Efficacy and tolerability of systemic methylprednisolone in children and adolescents with chronic rhinosinusitis: A double-blind, placebo-controlled randomized trial  Fadıl Ozturk, MD, Arzu Bakirtas, MD, Fikret Ileri, MD, Ipek Turktas, MD  Journal of Allergy and Clinical Immunology  Volume 128, Issue 2, Pages 348-352 (August 2011) DOI: 10.1016/j.jaci.2011.04.045 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Mean change from baseline in symptom and CT scan scores. Columns and error bars represent means and 95% CIs. CS, Cough score (P = .009); CTS, CT scan score (P = .004); H/FPS, headache or facial pain score (P > .05); HS, halitosis score (P > .05); MP, methylprednisolone; NDS, nasal discharge score (P > .05); NOS, nasal obstruction score (P = .001); P, placebo; PDS, postnasal discharge score (P = .007); TSS, total symptom score (P = .001). Journal of Allergy and Clinical Immunology 2011 128, 348-352DOI: (10.1016/j.jaci.2011.04.045) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions