Volume 127, Issue 2, Pages (February 2005)

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Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Reduction of Resuscitation Fluid Volumes in Severely.

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Volume 127, Issue 2, Pages 613-621 (February 2005) Early Treatment With Pentoxifylline Reduces Lung Injury Induced by Acid Aspiration in Rats Michael T. Pawlik, MD, Andreas G. Schreyer, MD, Karl P. Ittner, MD, Christoph Selig, MD, Michael Gruber, PhD, Stefan Feuerbach, MD, Kai Taeger, MD CHEST Volume 127, Issue 2, Pages 613-621 (February 2005) DOI: 10.1378/chest.127.2.613 Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 1. Effects of pentoxifylline (PTX) on Pao2. Data are presented as mean ± SD *p < 0.001 compared with placebo (PLC). FiO2 = fraction of inspired oxygen. CHEST 2005 127, 613-621DOI: (10.1378/chest.127.2.613) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 2. Effects of pentoxifylline on pH. Data are presented as mean ± SD. *p < 0.05 compared with placebo. See Figure 1 legend for expansion of abbreviations. CHEST 2005 127, 613-621DOI: (10.1378/chest.127.2.613) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 3. Effects of pentoxifylline on Paco2. No significant differences between the two treatment groups were found. Data are presented as mean ± SD. See Figure 1 legend for expansion of abbreviations. CHEST 2005 127, 613-621DOI: (10.1378/chest.127.2.613) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 4. Effects of pentoxifylline on MABP (top) and HR (bottom). Pentoxifylline alleviated the reduction in hemodynamic parameters produced by acid aspiration. Data are presented as mean ± SD *p < 0.05 compared with placebo. See Figure 1 legend for expansion of abbreviations. CHEST 2005 127, 613-621DOI: (10.1378/chest.127.2.613) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 5. Kaplan-Meier survival curves of all animals classified according to pentoxifylline or placebo treatment. Survival was significantly better in the PTX group (p < 0.02). Data represent percentage survival of 12 placebo-treated rats and 12 pentoxifylline-treated rats up to 6 h after acid aspiration. See Figure 1 legend for expansion of abbreviations. CHEST 2005 127, 613-621DOI: (10.1378/chest.127.2.613) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 6. Top: Spiral CT scan of the upper thorax reveals air-filled lungs of a pentoxifylline-treated animal with slightly increased lung attenuation. Bottom: Color-coding of the density values allows visualization of even subtle changes within the lung tissue (blue indicates air-filled lung tissue, green indicates edema, and red indicates atelectasis). CHEST 2005 127, 613-621DOI: (10.1378/chest.127.2.613) Copyright © 2005 The American College of Chest Physicians Terms and Conditions

Figure 7. Top: Spiral CT scan of a surviving placebo-treated rat lung demonstrating increased attenuation with some minor consolidation. Bottom: Color-coded imaging results in a green to yellow or red appearance (blue indicates air-filled lung tissue, green indicates edema, and red indicates atelectasis). CHEST 2005 127, 613-621DOI: (10.1378/chest.127.2.613) Copyright © 2005 The American College of Chest Physicians Terms and Conditions