Plasma insulin concentrations (A) and insulin secretion rates (B) in response to molar increments of plasma glucose concentration during the graded glucose infusion in the obese (•) and nonobese (□) groups. Plasma insulin concentrations (A) and insulin secretion rates (B) in response to molar increments of plasma glucose concentration during the graded glucose infusion in the obese (•) and nonobese (□) groups. Clare N. O. Jones et al. Am J Physiol Endocrinol Metab 2000;278:E501-E508 ©2000 by American Physiological Society