Insulin secretion rates during graded intravenous glucose infusions administered to 6 MODY-2 subjects with glucokinase (GCK) mutations and 6 control subjects.

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Insulin secretion rates during graded intravenous glucose infusions administered to 6 MODY-2 subjects with glucokinase (GCK) mutations and 6 control subjects after an overnight fast (baseline) and a 42-h intravenous infusion of glucose (postglucose) at a rate of 4 to 6 mg · kg−1 · min−1. Administration of the glucose infusion enhanced the insulin secretory response to glucose in both control and glucokinase-deficient subjects. Data are expressed as means ± SE. (Reproduced from Froguel.154 Used with permission.) Source: β-Cell Dysfunction in Type 2 Diabetes: Pathophysiological and Genetic Bases, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: https://ommbid.mhmedical.com/DownloadImage.aspx?image=/data/books/971/ch67fg12.png&sec=62671505&BookID=971&ChapterSecID=62671419&imagename= Accessed: November 12, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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